- C21 steroidal glycosides from Prunella Vulgaris
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A new C21 steroidal glycoside, qinyangshengenin-3-O-β-D-digitoxopyranoside (1), together with a known steroidal glycoside, qinyangshengenin-3-O-β-D-oleandropyranosyl-(1→4)-β-D-cymaropyranosyl-(1→4)-β-D-digitoxopyranoside (2), was isolated from
- Lou, Hua-Yong,Yao, Jia-Ning,Pan, Jie,Zheng, Shan,Liu, Ya-Zhou,Liang, Guang-Yi,Pan, Wei-Dong
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- New pregnane glycosides from the roots of Cynanchum otophyllum
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Six new pregnane glycosides with an acyl at C-12 and a straight sugar chain at C-3, namely otophyllosides H-M (1-6), were isolated from the roots of Cynanchum otophyllum (Asclepiadaceae) collected from Eryuan County in Yunnan province of China. Their stru
- Ma, Xiao-Xia,Jiang, Fang-Ting,Yang, Qing-Xiong,Liu, Xiu-Hua,Zhang, Ying-Jun,Yang, Chong-Ren
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- Cytotoxicity of pregnane glycosides of Cynanchum otophyllum
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Fourteen new pregnane glycosides, including nine caudatin glycosides (1-9), three qinyangshengenin glycosides (10-12), one kidjoranin glycosides (13) and one gagaminin glycosides (14), along with twelve known analogs (15-26) were isolated from roots of Cy
- Zhang, Mi,Li, Xiang,Xiang, Cheng,Qin, Yi,He, Jing,Li, Bao-Cai,Li, Peng
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- Cynanauriculoside C-E, three new antidepressant pregnane glycosides from Cynanchum auriculatum
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Based on the bioactive screening results, three new pregnane glycosides named as cynanauriculoside C-E (1-3), were isolated from the roots of Cynanchum auriculatum Royle ex Wight (Asclepiadaceae), together with two known ones, otophylloside L (4) and cynauricuoside C (5). On the basis of detailed spectroscopic analysis and chemical method, the structures of new compounds were characterized to be qingyangshengenin 3-O-β-d-oleandropyranosyl-(1 → 4)-β-d-cymaropyranoside (1), qingyangshengenin 3-O-β-d-glucopyranosyl- (1 → 4)-β-d-glucopyranosyl-(1 → 4) -α-l-cymaropyranosyl-(1 → 4)-β-d-oleandropyranosyl-(1 → 4)-β-d-cymaropyranoside (2) and caudatin 3-O-β-d-glucopyranosyl-(1 → 4)-β-d-glucopyranosyl-(1 → 4)-β-d-cymaropyranosyl-(1 → 4)-β-d-oleandropyranosyl-(1 → 4)-β-d-digitoxopyranoside (3). In the despair mice models, these pregnane glycosides showed significant antidepressant activity at the dosage of 50 mg/kg (i.g.). The most potent one was cyanauriculatoisde D (2), which was close to the positive control fluoxetine (20 mg/kg).
- Yang, Qing-Xiong,Ge, Yong-Chang,Huang, Xiao-Yan,Sun, Qian-Yun
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experimental part
p. 170 - 175
(2012/05/04)
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- Identification of new qingyangshengenin and caudatin glycosides from the roots of Cynanchum otophyllum
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HPLC analysis of the roots of Cynanchum otophyllum Scheind (Asclepiadaceae) led to the isolation of six new pregnane glycosides, specifically otophyllosides N-P (2-4) and otophyllosides Q-S (7-9), in addition to the identification of three known C-21 steroidal glycosides, otophylloside A (1), otophylloside B (5) and caudatin 3-O-β-d-glucopyranosyl-(1→4)-β- d-oleandropyranosyl-(1→4)-β-d-cymaropyranosyl-(1→4) -β-d-cymaropyranoside (6). The structure of each glycoside was determined by detailed spectroscopic analysis and chemical methods. All compounds contain qingyangshengenin or caudatin aglycones and a straight sugar chain consisting of 4-7 hexosyl moieties with the mode of 1→4 linkage. The optically isomeric monosaccharides, d- and l-cymarose, coexisted in both otophyllosides R (8) and S (9).
- Ma, Xiao-Xia,Wang, Dong,Zhang, Ying-Jun,Yang, Chong-Ren
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body text
p. 1003 - 1009
(2011/09/15)
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- C21 steroidal glycosides from Cynanchum wilfordii
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Eight new C21 steroidal glycosides, named wilfosides A-H (1 - 8, resp.), along with one known compound wilfoside KIN (9), were isolated from the roots of Cynanchum wilfordii. The structures of the new glycosides were determined on the basis of
- Xiang, Wen-Juan,Ma, Lei,Hu, Li-Hong
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experimental part
p. 2659 - 2674
(2010/04/04)
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