POTENTIAL NOOTROPIC AGENTS: SYNTHESIS OF A SERIES OF (2-OXO-1-PYRROLIDINYL)ACETIC ACID PIPERAZIDES
The title compounds VI-XXIII were prepared by heating ethyl (2-oxo-1-pyrrolidinyl)acetate (II) with a series of N-monosubstituted piperazines.The propionamides XXVI and XXX were obtained by reactions of the acid chlorides IV and XXXIII with 3-(1-piperazinyl)propionamide.Compounds VI (VUFB-13 763) and VIII (VUFB-14 745) proved more active than piracetam (I) by their antiamnestic effects in rats by antagonising the brain demaging effects of cycloheximide in infantile rats, and by their potentation of the effects of anticolvunsant agents.
Valenta, Vladimir,Sindelar, Karel,Holubek, Jiri,Ryska, Miroslav
p. 1613 - 1629
(2007/10/02)
Synthesis and pharmacological study of new piracetam derivatives and their thio analogs