Synthesis and SAR studies of 3-phenoxypropyl piperidine analogues as ORL1 (NOP) receptor agonists
A series of 3-phenoxypropyl piperidine analogues have been discovered as novel ORL1 receptor agonists. Structure-activity relationships have been explored around the 3-phenoxypropyl region with several potent and selective analogues identified.
Palin, Ronald,Barn, David R.,Clark, John K.,Cottney, Jean E.,Cowley, Phillip M.,Crockatt, Marc,Evans, Louise,Feilden, Helen,Goodwin, Richard R.,Griekspoor, Frank,Grove, Simon J.A.,Houghton, Andrea K.,Jones, Philip S.,Morphy, Richard J.,Smith, Alasdair R.C.,Sundaram, Hardy,Vrolijk, David,Weston, Mark A.,Wishart, Grant,Wren, Paul
p. 589 - 593
(2007/10/03)
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