cas 848185-12-6, 7-bromo-3-methyl-1,2,3,4-tetrahydroisoquinoline | Articles data ｜lookchem

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848185-12-6

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4, 6-DISUBSTITUTED 2-AMINO-PYRIMIDINES AS HISTAMINE H4 RECEPTOR MODULATORS
The present invention relates to substituted heterocyclic compounds of Formula (I) or pharmaceutically acceptable salts or N-oxides or quaternary ammonium salts thereof wherein constituent members are provided hereinwith, as well as their compositions and methods of use, which are histamine H4 receptor inhibitors/antagonists useful in the treatment of histamine H4 receptor-associated conditions or diseases or disorders including, for example, inflammatory diseases or disorders, pruritus, and pain.
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Page/Page column 98

(2010/07/09)

Exploring the active site of phenylethanolamine N-methyltransferase: 3-alkyl-7-substituted-1,2,3,4-tetrahydroisoquinoline inhibitors
A series of 3-alkyl-7-substituted-1,2,3,4-tetrahydroisoquinolines was synthesized and these compounds were evaluated for their PNMT inhibitory potency and affinity for the α2-adrenoceptor. 7-Nitro-, 7-bromo-, 7-aminosulfonyl-, or 7-N-2,2,2-trif
Grunewald, Gary L.,Romero, F. Anthony,Chieu, Alex D.,Fincham, Kelcie J.,Bhat, Seema R.,Criscione, Kevin R.
p. 1261 - 1273
(2007/10/03)

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Chemical Properties

Boiling Point: 288.8 °C at 760 mmHg
Flash Point:128.4 °C
Density: 1.342 g/cm³
PSA: 12.03000
LogP: 2.81210

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