- Facile synthesis of 5-acyl-2-amino-1,3-thiazole by the reaction of thiaazadienes with α-halo ketones
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The reaction of thiaazadienes (1a-e) with α-halo ketones (2a-d) gives 5-acyl-2-amino-1,3-thiazole (3a-q) in high yields.
- Sathunuru, Ramadas,Biehl, Ed
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p. 2805 - 2812
(2007/10/03)
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- Synthesis and characterisation of N,N-disubstituted 2-amino-5-acylthiophenes and 2-amino-5-acylthiazoles
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Starting from halomethyl-ketones 8 and N,N′-persubstituted thioacrylamides 7 or their 2-aza analogues 11 a series of N,N-disubstituted 2-amino-5-acylthiophenes 10 and 2-amino-5-acylthiazoles 12, respectively are available. By starting from 1,3-dichloroacetone and using the same thioacrylamide derivatives 7 and 11 N,N-disubstituted 2-amino-5-(chloroacetyl)thiophenes 13 and 2-amino-5-(chloroacetyl)thiazoles 14 as well as N,N′-persubstituted bis-(2-amino-5-thienyl)ketones 15, 2-amino-5-thienyl-(2-amino-5-thiazolyl)ketones 16, and bis-(2-amino-5-thiazolyl)ketones 17, respectively are available.
- Noack, Antje,Hartmann, Horst
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p. 2137 - 2146
(2007/10/03)
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- An Easy General Synthesis of 2-(N,N-Dialkylamino)thiazol-5-yl Aldehydes and Ketones
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Reaction between 2-chloro-5-thiazolyl-lithium and N,N-dialkylformamides or amides gave 2-N,N-dialkylaminothiazol-5-yl aldehydes or ketones on quenching with water.Quenching with acid gave 2-chlorothiazole-5-yl aldehydes or ketones, from which chloride was easily displaced by free amines.
- Sawhney, Indu,Wilson, John R. H.
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p. 329 - 331
(2007/10/02)
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