848422-75-3

Basic information

• Product Name: 5-(4-METHOXY-PHENYL)-7-TRIFLUOROMETHYL-PYRAZOLO[1,5-A]PYRIMIDINE-3-CARBONYL CHLORIDE
• Synonyms: ART-CHEM-BB B011661;5-(4-METHOXY-PHENYL)-7-TRIFLUOROMETHYL-PYRAZOLO[1,5-A]PYRIMIDINE-3-CARBONYL CHLORIDE;AKOS B011661
• CAS NO: 848422-75-3
• Molecular Formula: C₁₅H₉ClF₃N₃O₂
• Molecular Weight: 355.7
• Mol File: 848422-75-3.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 5-(4-METHOXY-PHENYL)-7-TRIFLUOROMETHYL-PYRAZOLO[1,5-A]PYRIMIDINE-3-CARBONYL CHLORIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 5-(4-METHOXY-PHENYL)-7-TRIFLUOROMETHYL-PYRAZOLO[1,5-A]PYRIMIDINE-3-CARBONYL CHLORIDE(848422-75-3)
• EPA Substance Registry System: 5-(4-METHOXY-PHENYL)-7-TRIFLUOROMETHYL-PYRAZOLO[1,5-A]PYRIMIDINE-3-CARBONYL CHLORIDE(848422-75-3)

Safety Data

• Hazardous Substances Data: 848422-75-3(Hazardous Substances Data)

Upstream product

• 333761-74-3 5-(4-methoxyphenyl)-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-3-carboxylic acid methyl ester 
• 15191-68-1 4,4,4-trifluoro-1-(4-methoxyphenyl)-1,3-butanedione 
• 100-06-1 1-(4-methoxyphenyl)ethanone 
• 333761-72-1 5-(4-methoxyphenyl)-7-(trifluoromethyl)-pyrazolo[1,5-a]pyrimidine-3-carboxylic acid 

Downstream Products

• 1076205-79-2 C₂₇H₂₄F₄N₄O₂ 
• 848431-90-3 2-({[5-(4-methoxyphenyl)-7-(trifluoromethyl)pyrazolo-[1,5-a]-pyrimidin-3-yl]carbonyl}amino)-4,5,6,7-tetrahydrobenzo[b]-thiophene-3-carboxamide 

Relevant articles and documents

Optimization of small-molecule inhibitors of influenza virus polymerase: From thiophene-3-carboxamide to polyamido scaffolds

Influenza virus infections represent a serious concern to public health, being characterized by high morbidity and significant mortality. To date, compounds targeting the viral ion-channel M2 or the viral neuraminidase are the drugs available for treatment of influenza, but the emergence of drug-resistant viral mutants renders the search for novel targets and their possible inhibitors a major priority. Recently, we demonstrated that the viral RNA-dependent RNA polymerase (RdRP) complex can be an optimal target of protein-protein disruption by small molecules, with thiophene-3-carboxamide derivatives emerging as promising candidates for the development of new anti-influenza drugs with broad-spectrum activity. Here, we report a further dissection of the thiophene-3-carboxamide structure. By using a GRID molecular interaction field (MIF)-based scaffold-hopping approach, more potent and nontoxic polyamido derivatives were identified, highlighting a new space in the chemical variability of RdRP inhibitors. Finally, a possible pharmacophoric model highlighting the key features required for RdRP inhibition is proposed.

ALPHA-UNSUBSTITUTED ARYLMETHYL PIPERAZINE PYRAZOLO[1,5-A] PYRIMIDINE AMIDE DERIVATIVES

Methods of preventing, treating or delaying the onset of HIV in a subject by administering to the subject novel pharmaceutically active arylmethyl pyrazolo[1,5-α ]pyrimidine amide derivatives, or pharmaceutical compositions containing the same are described. Additionally, compounds of novel pharmaceutically active arylmethyl piperazine pyrazolo[l,5-α]pyrimidine amide derivatives and their use for the manufacture of specific medicaments are described.