848774-96-9

Basic information

• Product Name: 2-(CHLOROMETHYL)NICOTINONITRILE
• Synonyms: 2-(CHLOROMETHYL)NICOTINONITRILE;2-(Chloromethyl)-3-cyanopyridine;2-(ChloroMethyl)pyridine-3-carbonitrile
• CAS NO: 848774-96-9
• Molecular Formula: C7H5ClN2
• Molecular Weight: 152.58
• Mol File: 848774-96-9.mol

Chemical Properties

• Boiling Point: 254.4±25.0 °C(Predicted)
• Appearance: /
• Density: 1.26
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: 0.27±0.22(Predicted)
• CAS DataBase Reference: 2-(CHLOROMETHYL)NICOTINONITRILE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(CHLOROMETHYL)NICOTINONITRILE(848774-96-9)
• EPA Substance Registry System: 2-(CHLOROMETHYL)NICOTINONITRILE(848774-96-9)

Safety Data

• Hazardous Substances Data: 848774-96-9(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
2-(Chloromethyl)nicotinonitrile is used as a key building block for the synthesis of various pharmaceuticals. Its unique structure allows for the creation of a wide range of medicinal compounds, contributing to the development of new treatments and therapies.
Used in Agrochemical Industry:
In the agrochemical sector, 2-(Chloromethyl)nicotinonitrile is utilized as an essential intermediate in the production of agrochemicals. Its role in the synthesis of these compounds helps to improve crop protection and enhance agricultural productivity.
As a Hazardous Chemical:
2-(Chloromethyl)nicotinonitrile is considered a hazardous chemical and should be handled with caution. It can cause skin and eye irritation, and may be harmful if inhaled or ingested. Proper safety measures and handling procedures must be followed to minimize potential risks during its use in various applications.

Upstream product

• 1721-23-9 2-methyl-nicotinonitrile 
• 115012-11-8 2-(hydroxymethyl)nicotinamide 

Relevant articles and documents

8-(3-AMINO-PIPERIDIN-1-YL)-XANTHINES, THEIR PREPARATION, AND THEIR USE AS PHARMACEUTICALS

The invention relates to 8-[3-amino-piperidin-1-yl]-xanthines and the physiologically acceptable salts thereof, particularly the hydrochlorides thereof.

METHOD FOR PRODUCING CHIRAL 8-(3-AMINO-PIPERIDIN-1-YL)-XANTHINES

The invention relates to an improved method for producing enantiomer-free 8-(3-amino-piperidin-1-yl)-xanthines.

8-[3-AMINO-PIPERIDIN-1-YL]-XANTHINE, THE PRODUCTION THEREOF AND THE USE IN THE FORM OF A DPP INHIBITOR

The invention relates to substituted xanthines of general formula (I), wherein R is such as defined in claim 1, and to the tautomers, stereoisomers, mixtures and the salts thereof, said products exhibiting precious pharmacological properties, in particular an inhibiting effect on a dipeptidylpeptidasa-IV (DPP-IV) enzyme activity.

Discovery of functionally selective 7,8,9,10-tetrahydro-7,10-ethano-1,2,4- triazolo[3,4-a]phthalazines as GABAA receptor agonists at the α3 subunit

We have previously identified the 7,8,9,10-tetrahydro-7,10-ethano-1,2,4- triazolo[3,4-a]phthalazine (1) as a potent partial agonist for the 0.3 receptor subtype with 5-fold selectivity in binding affinity over α1. This paper describes a detailed investigation of the substituents on this core structure at both the 3- and 6-positions. Despite evaluating a wide range of groups, the maximum selectivity that could be achieved in terms of affinity for the α3 subtype over the α1 subtype was 12-fold (for 57). Although most analogues showed no selectivity in terms of efficacy, some did show partial agonism at α1 and antagonism at α3 (e.g., 25 and 75). However, two analogues tested (93 and 96), both with triazole substituents in the 6-position, showed significantly higher efficacy for the α3 subtype over the α1 subtype. This was the first indication that selectivity in efficacy in the required direction could be achieved in this series.