Tocopherol derivatives with a long hydroxylated chain, which can be used as neurotrophics
The invention relates to any isolated or synthetic compound and, in particular, to compounds having formula which can: modulate the cell specification of neural stem cells, promote the differentiation and subsequent survival of differentiating glial cells
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Page/Page column 6
(2008/06/13)
Improved synthesis of tocopherol fatty alcohols and analogs: microglial activation modulators
The synthesis of tocopherol fatty alcohols (TFAs), potent microglial activation modulators, was achieved via C-alkylation of trimethylhydroquinone. Several analogs, in particular water-soluble prodrugs, have been synthesized using a Wittig reaction and th
Muller, Thierry,Coowar, Djalil,Hanbali, Mazen,Heuschling, Paul,Luu, Bang
p. 12025 - 12040
(2007/10/03)
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