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848818-35-9

8-chloro-3-Methyl-2H-pyrazolo[4,3-c]quinolin-4(5H)-one is a chemical with a specific purpose. Lookchem provides you with multiple data and supplier information of this chemical.

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  • 848818-35-9 Structure

  • Basic information

    1. Product Name: 8-chloro-3-Methyl-2H-pyrazolo[4,3-c]quinolin-4(5H)-one
    2. Synonyms: 8-chloro-3-Methyl-2H-pyrazolo[4,3-c]quinolin-4(5H)-one
    3. CAS NO:848818-35-9
    4. Molecular Formula: C11H8ClN3O
    5. Molecular Weight: 233.65372
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 848818-35-9.mol

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: /
    5. Density: N/A
    6. Refractive Index: N/A
    7. Storage Temp.: 2-8°C
    8. Solubility: N/A
    9. CAS DataBase Reference: 8-chloro-3-Methyl-2H-pyrazolo[4,3-c]quinolin-4(5H)-one(CAS DataBase Reference)
    10. NIST Chemistry Reference: 8-chloro-3-Methyl-2H-pyrazolo[4,3-c]quinolin-4(5H)-one(848818-35-9)
    11. EPA Substance Registry System: 8-chloro-3-Methyl-2H-pyrazolo[4,3-c]quinolin-4(5H)-one(848818-35-9)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 848818-35-9(Hazardous Substances Data)

848818-35-9 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 848818-35-9 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 8,4,8,8,1 and 8 respectively; the second part has 2 digits, 3 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 848818-35:
(8*8)+(7*4)+(6*8)+(5*8)+(4*1)+(3*8)+(2*3)+(1*5)=219
219 % 10 = 9
So 848818-35-9 is a valid CAS Registry Number.

848818-35-9SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 17, 2017

Revision Date: Aug 17, 2017

1.Identification

1.1 GHS Product identifier

Product name 8-chloro-3-methyl-1,2-dihydropyrazolo[4,3-c]quinolin-4-one

1.2 Other means of identification

Product number -
Other names -

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:848818-35-9 SDS

848818-35-9Downstream Products

848818-35-9Relevant articles and documents

Optimization of a pyrazoloquinolinone class of Chk1 kinase inhibitors

Brnardic, Edward J.,Garbaccio, Robert M.,Fraley, Mark E.,Tasber, Edward S.,Steen, Justin T.,Arrington, Kenneth L.,Dudkin, Vadim Y.,Hartman, George D.,Stirdivant, Steven M.,Drakas, Bob A.,Rickert, Keith,Walsh, Eileen S.,Hamilton, Kelly,Buser, Carolyn A.,Hardwick, James,Tao, Weikang,Beck, Stephen C.,Mao, Xianzhi,Lobell, Robert B.,Sepp-Lorenzino, Laura,Yan, Youwei,Ikuta, Mari,Munshi, Sanjeev K.,Kuo, Lawrence C.,Kreatsoulas, Constantine

, p. 5989 - 5994 (2008/03/14)

The development of 2,5-dihydro-4H-pyrazolo[4,3-c]quinolin-4-ones as inhibitors of Chk1 kinase is described. Introduction of a fused ring at the C7/C8 positions of the pyrazoloquinolinone provided an increase in potency while guidance from overlapping inhibitor bound Chk1 X-ray crystal structures contributed to the discovery of a potent and solubilizing propyl amine moiety in compound 52 (Chk1 IC50 = 3.1 nM).

CHK-1 INHIBITORS

-

Page/Page column 114, (2010/02/11)

Disclosed are novel inhibitors of Chk-1 and methods of using the same for therapy.

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