848953-51-5Relevant articles and documents
Design and optimization of potent, selective antagonists of Oxytocin
Brown, Alan,Brown, Lindsay,Ellis, Dave,Puhalo, Nicholas,Smith, Chris R.,Wallace, Olga,Watson, Lesa
scheme or table, p. 4278 - 4281 (2009/04/06)
A novel series of Oxytocin antagonists are described. This series was identified through pharmacophoric overlap of in-house and literature antagonists. Subsequent optimization led to a series of potent, selective antagonists. Several analogues displayed o
SUBSTITUTED TRIAZOLE DERIVATIVES AS OXYTOCIN ANTAGONISTS
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Page/Page column 99, (2010/02/11)
The present invention relates to a class of substituted 1,2,4-triazoles of formula (I) with activity as oxytocin antagonists, uses thereof, processes for the preparation thereof and compositions containing, said, inhibitors. These inhibitors have utility in a variety of therapeutic areas including sexual dysfunction, particularly premature ejaculation (P.E.).