Nonpolar and short side chain groups at C-11β of estradiol result in antiestrogens
We have previously found that esters of 11β-estradiol carboxylates are transformed from an estrogen into an antiestrogen when the 11β-side chain is increased in length from four to five non-hydrogen atoms (n ≥ 5). To understand the structural requirements
Zhang, Jing-Xin,Labaree, David C.,Hochberg, Richard B.
p. 1428 - 1447
(2007/10/03)
11beta-short chain substituted estradiol analogs and their use in the treatment of menopausal symptoms and estrogen sensitive cancer
The present invention relates to novel 11-β estradiol ester compounds and their use as locally active estrogens in the treatment of the symptomology of menopause and to treat estrogen sensitive cancers, including breast cancer.
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Page/Page column 6; sheet 11
(2010/02/07)
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