849659-42-3Relevant articles and documents
Discovery and SAR development of thienopyridones: A class of small molecule AMPK activators
Zhao, Gang,Iyengar, Rajesh R.,Judd, Andrew S.,Cool, Barbara,Chiou, William,Kifle, Lemma,Frevert, Ernst,Sham, Hing,Kym, Philip R.
, p. 3254 - 3257 (2008/02/08)
AMP-activated protein kinase (AMPK) is well established as a sensor and regulator of intracellular and whole-body energy metabolism. A high-throughput screen was performed in order to identify chemotypes that are bound by AMPK. A novel thienopyridone comp
Aryl alkyl ketones in a one-pot Gewald synthesis of 2-aminothiophenes
Tormyshev, Victor M.,Trukhin, Dmitry V.,Rogozhnikova, Olga Yu.,Mikhalina, Tatiana V.,Troitskaya, Tatiana I.,Flinn, Anthony
, p. 2559 - 2564 (2008/09/16)
2-Aminothiophene-3-carboxylates bearing various aryl groups at the 4-position are readily obtained in good to moderate yields by the one-pot Gewald reaction of aryl alkyl ketones with ethyl cyanoacetate and elemental sulfur in the presence of morpholinium acetate and excess morpholine. Georg Thieme Verlag Stuttgart.