- Synthesis of N-unsubstituted cyclic imides from anhydride with urea in deep eutectic solvent (DES) choline chloride/urea
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N-Unsubstituted cyclic imides were readily synthesized in deep eutectic solvent (DES) choline chloride (ChCl)/urea from anhydrides with urea. Urea serves as both a DES component and a nitrogen source, which endows the protocol with advantages of smooth reaction, easy separation of products, simple recovery and recycling of ChCl/urea.
- Liu, Luxiao,Zhang, Hong-Yu,Yin, Guohui,Zhang, Yuecheng,Zhao, Jiquan
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p. 1351 - 1357
(2019/11/19)
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- Preparation method of 1,2,3,6-tetrahydrophthalimide
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The invention provides a preparation method of 1,2,3,6-tetrahydrophthalimide. The preparation method comprises the following steps: a) mixing 1,2,3,6-tetrahydrophthalic anhydride with an ammonia source, and carrying out a low-temperature reaction to obtain a reaction intermediate, wherein the temperature of the low-temperature reaction is 0-30 DEG C; and b) carrying out a dehydration ring-closurereaction on the reaction intermediate obtained in the step a) in the presence of a solvent, carrying out cooling and recrystallizing to obtain the 1,2,3,6-tetrahydrophthalimide. According to the preparation method provided by the invention, a step-by-step method is adopted, a ring-opening reaction and a ring-closure reaction are separated to reduce side reactions, and a conventional heating process is not carried out in the whole process, so the generation of viscous colloidal byproducts in a temperature range of 80-110 DEG C can be effectively avoided, and high selectivity is realized, thereby improving product purity; meanwhile, reaction operation in a solvent is simple, conditions are easy to control, and environment friendliness is achieved; the overall two-step yield can reach 95% orhigher; moreover, no waste gas is generated in the reaction process, and redundant ammonia gas can be recycled, so environmental production cost is greatly saved.
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Paragraph 0061; 0063; 0064; 0066; 0067; 0069; 0070; 0072
(2020/01/12)
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- AMIDOALKYLPIPERAZINYL DERIVATIVES FOR THE TREATMENT OF CENTRAL NERVOUS SYSTEM DISEASES
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The invention relates to novel amidoalkylpiperazinyl derivatives of tricyclic heterocyclic systems of general formula (I), wherein Z represents -NH- and X represents -S-, or Z represents -S- and X represents >C=C1 represents H or -CH3, R6 and R7 both represent H, n is an integer from 0 to 4 inclusive, G represents a cyclic amide or imide moiety, and optical isomers, geometric isomers, and pharmaceutically acceptable salts thereof. The compounds may be useful for the treatment and/or prevention of the central nervous system disorders.
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Page/Page column 28; 29
(2013/03/26)
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- Diels-Alder reactions of hexachlorocyclopentadiene with N-hydroxy- and N-hydroxyalkyl-cis-4-cyclohexene-1,2-dicarboximides
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The Diels-Alder reaction of hexachlorocyclopentadiene with N-hydroxymethyl-cis-4-cyclohexene-1,2-dicarboximide is accompanied by partial or complete elimination of formaldehyde molecule. The desired stable polychlorinated Diels-Alder adducts are obtained from substrates in which the hydroxy group is protected by acetylation and those containing a trichloromethyl group in the α-position or lacking the methylene group.
- Salakhov,Agadzhanov,Umaeva
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p. 1313 - 1317
(2007/10/03)
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- INCORPORATION OF MOLECULAR NITROGEN INTO AMIDES AND IMIDES BY USE OF TITANIUM-NITROGEN COMPLEXES
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Molecular nitrogen was incorporated into amides and imides by the reaction of titanium-nitrogen complex 1 prepared from TiCl3 and Mg under N2 in THF with acyl chlorides 3.The cyclic imides 10, 12, 14 and quinazoline 16 were obtained by the reaction of isocyanate complex 6 generated by fixation of CO2 into titanium complex 1 with the corresponding cyclic anhydrides 9, 11, 13 and benzoxazone 15.
- Mori,Miwako,Uozumi, Yasuhiro,Shibasaki, Masakatsu
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p. 6187 - 6190
(2007/10/02)
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- OLEFIN CYCLISATIONS OF HINDERED α-ACYLIMINIUM IONS
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Stereocontrolled NaBH4/H+-reduction of 3,4-cis-disubstituted N-alkenyl imides 1-5 leads to secondary hydroxylactams.Tertiary hydroxylactams are formed via addition of MeMgCl to imides 2 and 4.HCOOH-Cyclisation of the hydroxylactams affords polycyclic piperidines through stereoselective α-acyliminium ring closure.Concomitant synchronous and stepwise cyclisation pathways are operative in the anti-periplanar addition of tertiary α-acyliminium ions to Me substituted olefins 8c and 11c.
- Wijnberg, B. P.,Speckamp, W. N.,Oostveen, A. R. C.
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p. 209 - 217
(2007/10/02)
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