Three-component synthesis of α,β-cyclopropyl-γ-amino acids
(Chemical Equation Presented) The multicomponent coupling of alkenylzirconocenes with N-diphenylphosphinoyl imines provides rapid access to functionalized C-cyclopropylalkylamides which have been readily transformed into α,β-cyclopropyl-γ-amino acids. The
Wipf, Peter,Stephenson, Corey R. J.
p. 1137 - 1140
(2007/10/03)
Application of divergent multi-component reactions in the synthesis of a library of peptidomimetics based on γ-amino-α,β-cyclopropyl acids
The multi-component condensation of organozirconocene, aldimine and zinc carbenoid was applied to the stereoselective synthesis of cyclopropane amino acid derivatives. These compounds served as scaffolds for the preparation of a 46-member library. The C-
Wipf, Peter,Werner, Stefan,Woo, Grace H.C.,Stephenson, Corey R.J.,Walczak, Maciej A.A.,Coleman, Claire M.,Twining, Leslie A.
p. 11488 - 11500
(2007/10/03)
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