Open-chain nitrogen compounds. Part XII. Methanolysis of 3-alkyl-3,4-dihydro-1,2,3-benzotriazin-4-ols: evidence for ring-chain tautomerism with the cytotoxic monoalkyltriazenes
A series of 4-hydroxy-3,4-dihydro-1,2,3-benzotriazines ("triazinols"), potential pro-drugs for the cytotoxic monoalkyltriazenes, have been investigated for anti-tumor activity and have been found to have marginal activity against the TLX5 tumor.The in-viv
LaFrance, Ronald,Manning, Hartford W.,Vaughan, Keith
p. 292 - 297
(2007/10/02)
Synthesis of 4-hydroxy-3,4-dihydro-1,2,3-benzotriazines via 2-(3-alkyl-1-triazeno)benzaldehydes and 2-(3-alkyl-1-triazeno)benzophenones
Diazotization of o-aminobenzaldehyde, followed by immediate coupling of the diazonium salt with primary alkylamines, affords unstable 1-aryl-3-alkyltriazenes which immediately cyclize to the 4-hydroxy-3-alkyl-1,2,3-benzotriazines.Analogous reaction of o-a
Faye, Patricia L.,Vaughan, Keith,Hooper, Donald L.
p. 179 - 183
(2007/10/02)
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