We have modified the previously reported 2-aminoquinoline 1 to provide two novel series of MCH-1R antagonists. Representative compounds from the quinazoline and benzimidazole series have been shown to be potent and selective, with promising in vitro eADME profiles.
Arienzo, Rosa,Cramp, Sue,Dyke, Hazel J.,Lockey, Peter M.,Norman, Dennis,Roach, Alan G.,Smith, Phil,Wong, Melanie,Wren, Stephen P.