Synthesis of 2,5-dihydrofurans via alkylidene carbene insertion reactions
The insertion reaction of alkylidene carbenes is demonstrated to be an effective method for the synthesis of 2,5-dihydrofuran ring systems. The best results have been obtained on substrates containing electron-withdrawing substituents, which appear less prone to the competing rearrangement reaction. This insight has led to the development of a new method for the synthesis of the core structure of the squalestatin-zaragozic acid natural products.
Walker, Louise F.,Bourghida, Ahmed,Connolly, Stephen,Wills, Martin
p. 965 - 981
(2007/10/03)
Synthesis of 2,5-dihydrofurans via alkylidene carbene insertion reactions
The insertion of vinylidene carbenes into C-H bonds is an efficient method for the synthesis of 2,5-dihydrofurans. The methodology provides a convenient entry to the core structure of squalestatin/zaragozic acid natural products.
Walker, Louise F.,Connolly, Stephen,Wills, Martin
p. 5273 - 5276
(2007/10/03)
More Articles about upstream products of 85061-03-6