- Electrochemical direct carboxylation of benzyl alcohols having an electron-withdrawing group on the phenyl ring: One-step formation of phenylacetic acids from benzyl alcohols under mild conditions
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Electrochemical direct carboxylation of benzyl alcohols having an electron-withdrawing group on the phenyl ring was successfully carried out by constant current electrolysis using an undivided cell equipped with a platinum plate cathode and a magnesium rod anode in DMF in the presence of carbon dioxide. Reductive cleavage of the C-O bond followed by fixation of carbon dioxide efficiently took place at the benzylic position without any additive to give the corresponding phenylacetic acids in good yields in one step under neutral and mild conditions.
- Senboku, Hisanori,Yoneda, Kenji,Hara, Shoji
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p. 6772 - 6776
(2016/01/30)
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- 2- and 2,5-substituted phenylketoenols
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The invention relates to novel phenyl-substituted cyclic ketoenols of the formula (I) in which Het represents one of the groups ?in which A, B, D, G, X and Z are each as defined in the description, to a plurality of processes and intermediates for their preparation, and to their use as pesticides.
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Page column 80
(2010/01/31)
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- Synthesis of dihalophenylacetic acids using aromatic nucleophilic substitution strategy
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A simple synthetic strategy to dihalophenylacetic acids and specifically 3,5-difluorophenylacetic acid an important pharmaceutical intermediate was developed. The aromatic nucleophilic substitution of dihalofluorobenzenes using the anion of ethyl cyanoacetate yielded ethyl dihalophenylcyanoacetates. The basic decarboxylation of the ethyl dihalophenylcyanoacetates produced targeted dihalophenylacetic acids.
- Kowalczyk, Bruce A.
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p. 1411 - 1414
(2007/10/03)
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