850689-36-0

Basic information

• Product Name: 3-AMINO-4-CHLOROPHENYLBORONIC ACID
• Synonyms: 3-AMINO-4-CHLOROPHENYLBORONIC ACID
• CAS NO: 850689-36-0
• Molecular Formula: C₆H₇BClNO₂
• Molecular Weight: 171.39
• Product Categories: Boronic Acid;Aryl;Organoborons
• Mol File: 850689-36-0.mol

Chemical Properties

• Boiling Point: 372.9±52.0 °C(Predicted)
• Appearance: /
• Density: 1.40±0.1 g/cm3(Predicted)
• Storage Temp.: 2-8°C
• PKA: 8.32±0.10(Predicted)
• CAS DataBase Reference: 3-AMINO-4-CHLOROPHENYLBORONIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 3-AMINO-4-CHLOROPHENYLBORONIC ACID(850689-36-0)
• EPA Substance Registry System: 3-AMINO-4-CHLOROPHENYLBORONIC ACID(850689-36-0)

Safety Data

• Hazardous Substances Data: 850689-36-0(Hazardous Substances Data)

Usage

Uses

Used in Organic Chemistry Research:
3-Amino-4-chlorophenylboronic acid is used as a reagent in organic chemistry for its unique properties, including its ability to act as a ligand, possess high thermal stability, and form stable covalent bonds.
Used in Pharmaceutical and Chemical Synthesis:
In the pharmaceutical and chemical synthesis industries, 3-Amino-4-chlorophenylboronic acid is used as a key component in Suzuki coupling reactions, a type of palladium-catalyzed cross-coupling reaction. This reaction is significant for the synthesis of complex organic molecules and the development of new pharmaceutical compounds.
Used in Suzuki Coupling Reactions:
3-Amino-4-chlorophenylboronic acid is utilized as a reactant in Suzuki coupling reactions, which are crucial for the formation of carbon-carbon bonds in the synthesis of various organic compounds. This reaction plays a vital role in the development of new pharmaceuticals and the advancement of chemical synthesis techniques.

Downstream Products

• 1126369-81-0 4-chloro-3-(4-(pyridin-2-ylmethoxy)benzamido)phenylboronic acid 
• 943917-74-6 methyl 4'chloro-2-methyl-3'-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)biphenyl-4-carboxylate 

Relevant articles and documents

Process for the preparation of aminoaryl- and aminoheteroaryl boronic acids and esters

The present invention relates to a process for the preparation of aminoaryl- and aminoheteroaryl boronic acids and esters of formula (I) in high yields The claimed process uses diarylketal formula (V) to generate an arylbromid of formula (III) in which the amino-group is protected as bisarylmethylidenimino-group:

PROCESS FOR THE PREPARATION OF AMINOARYL- AND AMINOHETEROARYL BORONIC ACIDS AND ESTERS

The present invention relates to a process for the preparation of aminoaryl- and aminoheteroaryl boronic acids and esters thereof of formula (I) in high yield. The claimed process uses diarylketal formula (V) to generate an arylbromide of formula (III) in which the amino-group is protected as bisarylmethylidenimino-group, which is then transformed into a formula (I) compound.