850728-18-6

Basic information

• Product Name: SN 2310
• Synonyms: SN 2310;Tenifatecan;Tocopherol succinate 7-ethyl-10-hydroxycamptothecin;d-alpha-Tocopherol succinate 7-ethyl-10-hydroxycamptothecin
• CAS NO: 850728-18-6
• Molecular Formula: C55H72N2O9
• Molecular Weight: 905.16818
• Mol File: 850728-18-6.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: SN 2310(CAS DataBase Reference)
• NIST Chemistry Reference: SN 2310(850728-18-6)
• EPA Substance Registry System: SN 2310(850728-18-6)

Safety Data

• Hazardous Substances Data: 850728-18-6(Hazardous Substances Data)

Usage

Uses

Used in Paints and Coatings Industry:
SN 2310 is used as a solvent and diluent for enhancing the performance and application properties of paints and coatings. Its unique combination of properties allows for improved flow, leveling, and drying characteristics, resulting in a high-quality finish.
Used in Adhesives Industry:
In the adhesives industry, SN 2310 is used as a solvent and diluent to improve the viscosity, adhesion, and bonding strength of adhesive formulations. Its controlled evaporation rate ensures a consistent application and optimal drying time.
Used in Inks Industry:
SN 2310 is used as a carrier and diluent in ink formulations, providing a stable and consistent flow of ink during printing processes. Its low vapor pressure helps maintain the integrity of the ink, preventing premature drying or clogging of the printing equipment.
Used in Cleaning Products Industry:
In the production of industrial and consumer cleaning products, SN 2310 is used as a solvent and diluent to dissolve and suspend various cleaning agents, fragrances, and other additives. Its mild odor and low toxicity make it suitable for use in a wide range of cleaning applications, from heavy-duty industrial cleaners to household cleaning products.
Overall, SN 2310's unique combination of properties makes it a versatile and effective ingredient for a wide range of industrial processes, including the manufacturing of paints, coatings, adhesives, inks, and cleaning products.

Upstream product

• 86639-52-3 7-ethyl-10-hydroxycamptothecin 
• 4345-03-3 vitamin E succinate 

Relevant articles and documents

Structure-Based Rational Design of Prodrugs to Enable Their Combination with Polymeric Nanoparticle Delivery Platforms for Enhanced Antitumor Efficacy

Drug-loaded nanoparticles (NPs) are of particular interest for efficient cancer therapy due to their improved drug delivery and therapeutic index in various types of cancer. However, the encapsulation of many chemotherapeutics into delivery NPs is often hampered by their unfavorable physicochemical properties. Here, we employed a drug reform strategy to construct a small library of SN-38 (7-ethyl-10-hydroxycamptothecin)-derived prodrugs, in which the phenolate group was modified with a variety of hydrophobic moieties. This esterification fine-tuned the polarity of the SN-38 molecule and enhanced the lipophilicity of the formed prodrugs, thereby inducing their self-assembly into biodegradable poly(ethylene glycol)-block-poly(d,l-lactic acid) (PEG-PLA) nanoparticulate structures. Our strategy combining the rational engineering of prodrugs with the pre-eminent features of conventionally used polymeric materials should open new avenues for designing more potent drug delivery systems as a therapeutic modality.

NOVEL PRO- AND CODRUG DERIVATIVES FOR NANOPARTICLE DELIVERY OF SELECT ANTICANCER AGENTS FORMED USING RAPIDLY CLEAVABLE PHENOLIC ESTER BRIDGES

An ester of ArOH according to the formula R-X-CO-OAr, wherein ArOH is a pharmaceutically active compound selected from the group consisting of SN-38, PI-103, etoposide and fenretinide, wherein a) R is a residue of cholesterol, sitosterol, SN-38, PI-103, etoposide or fenretinide and X is O-CO-L, wherein L is either a direct bond or a linking group including a branched or unbranched hydrocarbyl moiety that may optionally include in-chain or pendant heteroatom substituents and/or cyclic moieties; b) R-X-CO-0 is an all-trans retinoate radical or the 9-cis or 13-cis isomer thereof; or c) R-X- is a branched or unbranched, saturated or unsaturated hydrocarbyl moiety comprising at least 5 carbon atoms and optionally including at least one in-chain or pendant heteroatom substituent and/or cyclic moiety. A dispersion of nanoparticles in an aqueous medium includes nanoparticles including an ester of ArOH according to the formula R-X-CO-OAr wherein ArOH is a pharmaceutically active compound in which Ar is a substituted or unsubstituted aryl or heteroaryl radical, and wherein R is as defined above or R-X-CO-0 is as defined above. The ester or dispersion may be used to treat a diagnosed medical condition in a patient.

Tocopherol-modified therapeutic drug compounds

Tocopherol-modified therapeutic drug compounds; emulsion, microemulsion, and micelle formulations that include the compounds; methods for making the compounds and formulations; methods for administering the compounds and formulations; and methods for treating conditions using the compounds and formulations.