The discovery of 6-[2-(5-chloro-2-{[(2,4-difluorophenyl)methyl]oxy}phenyl)-1-cyclopenten- 1-yl]-2-pyridinecarboxylic acid, GW848687X, a potent and selective prostaglandin EP1 receptor antagonist for the treatment of inflammatory pain
The discovery of a series of selective EP1 receptor antagonists based on a 1,2-diarylcyclopentene template is described. After defining the structural requirements for EP1 potency and selectivity, heterocyclic rings were incorporated
Giblin, Gerard M.P.,Bit, Rino A.,Brown, Susan H.,Chaignot, Helene M.,Chowdhury, Anita,Chessell, Iain P.,Clayton, Nicholas M.,Coleman, Tanya,Hall, Adrian,Hammond, Beverley,Hurst, David N.,Michel, Anton D.,Naylor, Alan,Novelli, Riccardo,Scoccitti, Tiziana,Spalding, David,Tang, Sac P.,Wilson, Alex W.,Wilson, Rich
p. 385 - 389
(2007/10/03)
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