851335-07-4Relevant articles and documents
Ortho-substituted aryl monoboronic acids have improved selectivity for d-glucose relative to d-fructose and l-lactate
Hansen,Christensen,Solling,Jakobsen,Hoeg-Jensen
body text, p. 1334 - 1340 (2011/04/12)
Ortho-substituted aryl monoboronic acids have been found to have improved selectivity for d-glucose compared to d-fructose and l-lactate. These findings are supported by computational studies on the B3LYP/6-31G(d) level using Gaussian. This finding is of
AMINO ALCOHOL DERIVATIVE, MEDICINAL COMPOSITION CONTAINING THE SAME, AND USE OF THESE
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Page/Page column 36, (2008/06/13)
The present invention provides compounds represented by general formula (I): a prodrug thereof, or pharmaceutical acceptable salts thereof, wherein R1 is hydrogen or lower alkyl; each of R2 and R3 is independently hydrogen or lower alkyl; each of R4, R5 and R6 is independently hydrogen, halogen, lower alkyl or lower alkoxy; R7 is hydrogen or lower alkyl; R8 is hydrogen, halogen, lower alkyl, lower alkoxy, etc; R9 is -COR10, -A1-COR10, -O-A2-COR10, etc; Ar is optionally substituted phenyl or heteroaryl; and A is a bond, -OCH2-, etc, which exhibit potent and selective β3-adrenoceptor stimulating activities. The present invention also provides pharmaceutical compositions containing said compound, and uses thereof.