851528-84-2Relevant articles and documents
Synthesis and biological evaluation of 1-(2-hydroxy-3-phenyloxypropyl) piperazine derivatives as T-type calcium channel blockers
Park, Jung-Eun,Ji, Wan Keun,Jang, Jae Wan,Pae, Ae Nim,Choi, Keehyun,Choi, Ki Hang,Kang, Jahyo,Roh, Eun Joo
supporting information, p. 1887 - 1890 (2013/04/10)
To obtain selective and potent inhibitor for T-type calcium channel by ligand based drug design, 2-hydroxy-3-phenoxypropyl piperazine derivatives were synthesized and evaluated for in vitro activities. Compound 6m and 6q showed high selectivity over hERG
Discovery, synthesis, and biological evaluation of piperidinol analogs with anti-tuberculosis activity
Sun, Dianqing,Scherman, Michael S.,Jones, Victoria,Hurdle, Julian G.,Woolhiser, Lisa K.,Knudson, Susan E.,Lenaerts, Anne J.,Slayden, Richard A.,McNeil, Michael R.,Lee, Richard E.
experimental part, p. 3588 - 3594 (2009/10/10)
Direct anti-tuberculosis screening of commercially available compound libraries identified a novel piperidinol with interesting anti-tuberculosis activity and drug like characteristics. To generate a structure activity relationship about this hit a 22 mem
Discovery of para-alkylthiophenoxyacetic acids as a novel series of potent and selective PPARδ agonists
Zhang, Rui,Wang, Aihua,DeAngelis, Alan,Pelton, Patricia,Xu, Jun,Zhu, Peifang,Zhou, Lubing,Demarest, Keith,Murray, William V.,Kuo, Gee-Hong
, p. 3855 - 3859 (2008/02/13)
A novel series of potent and selective PPARδ agonists, para-alkylthiophenoxyacetic acids, was identified. The synthesis and structure-activity relationships are described.
4-((PHENOXYALKYL)THIO)-PHENOXYACETIC ACIDS AND ANALOGS
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Page/Page column 76, (2010/02/11)
The invention features 4-((phenoxyalkyl)thio)-phenoxyacetic acids and analogs, compositions containing them, and methods of using them as PPAR delta modulators to treat or inhibit the progression of, for example, dyslipidemia.