852570-80-0

Basic information

• Product Name: 5-BROMOISOQUINOLIN-1-AMINE
• Synonyms: 5-BROMOISOQUINOLIN-1-AMINE;1-Amino-5-bromoisoquinoline;5-Bromo-1-isoquinolinamine;5-Bromoisoquinolin-1-amine, 1-Amino-5-bromo-2-azanaphthalene;5-bromoisoquinolin-1-ylamine
• CAS NO: 852570-80-0
• Molecular Formula: C₉H₇BrN₂
• Molecular Weight: 223.07
• Product Categories: Building Blocks;Isoquinoline
• Mol File: 852570-80-0.mol

Chemical Properties

• Boiling Point: 380.7 °C at 760 mmHg
• Flash Point: 184 °C
• Appearance: /
• Density: 1.649
• Vapor Pressure: 5.35E-06mmHg at 25°C
• Refractive Index: 1.732
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• PKA: 6.50±0.43(Predicted)
• CAS DataBase Reference: 5-BROMOISOQUINOLIN-1-AMINE(CAS DataBase Reference)
• NIST Chemistry Reference: 5-BROMOISOQUINOLIN-1-AMINE(852570-80-0)
• EPA Substance Registry System: 5-BROMOISOQUINOLIN-1-AMINE(852570-80-0)

Safety Data

• Statements: 41
• Safety Statements: 26-39
• Hazardous Substances Data: 852570-80-0(Hazardous Substances Data)

Usage

Uses

Used in Medicinal Chemistry:
5-Bromoisoquinolin-1-amine is used as a building block for the synthesis of various bioactive molecules, contributing to the development of new pharmaceuticals with potential therapeutic applications.
Used in Pharmaceutical Intermediates:
5-Bromoisoquinolin-1-amine serves as a pharmaceutical intermediate, facilitating the creation of compounds that can be further modified or used in the production of drugs, enhancing the range of available treatments.
Used in Drug Discovery:
5-Bromoisoquinolin-1-amine is utilized in drug discovery processes, where its ability to interact with biological targets is explored for potential use in treating diseases and conditions, thereby expanding the scope of therapeutic interventions.

InChI:InChI=1/C9H7BrN2/c10-8-3-1-2-7-6(8)4-5-12-9(7)11/h1-5H,(H2,11,12)

Upstream product

• 34551-41-2 5-bromo-1-chloroisoquinoline 

Downstream Products

• 1481641-08-0 C₂₃H₂₃N₅O₂ 

Relevant articles and documents

BRIDGED BICYCLIC KALLIKREIN INHIBITORS

Provided herein are kallikrein modulating compounds, pharmaceutical compositions comprising the same, and uses thereof.

BIS-ARYL AMIDE DERIVATIVES AND METHODS OF USE

Selected compounds are effective for prophylaxis and treatment of diseases, such as c Met mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable salts thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving, cancer and the like. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.

SUBSTITUTE ISOQUINOLINES USEFUL IN THE TREATMENT OF DISEASES SUCH AS CANCER AND ATHEROSCLEROSIS

A compound of Formula (I) wherein: One of R1 and R2 is H and the other represents - NHCONHR4 wherein R4 represents a phenyl or naphthyl group (which may be optionally substituted by one or more substituents independently selected from -C1-6 alkyl, -C1-6 haloalkyl, - CH2CH2CH2-, halogen, C1-6 alkoxy, C1-6 haloalkoxy, OH, NO2), C3-7 cycloalkyl or R4 together with the NH to which it is bonded forms a morpholino group and R3 is H or NHR5 wherein R5 is H, -quinolinyl or -isoquinolinyl, -(CONH)p phenyl (wherein p is 0 or 1 and the phenyl is optionally substituted by one or more substituents independently selected from halogen, -C1-6 alkyl, -C1-6 haloalkyl, -morpholino, -SO2NH2, benzothiazole (substituted by methyl)) or a salt, solvate, or physiologically functional derivative thereof.

1-AMINO-ISOQUINOLINE DERIVATIVES FOR THE TREATMENT OF DISEASES ASSOCIATED WITH INAPPROPRIATE ALK5

A compound of Formula (I) wherein R1 represents a phenyl or napthyl group (each of which is optionally substituted by one or more substituents independently selected from -OH, -C1-6alkyl, C1-6haloalkyl, -OCH2OCH3, -C1-6alkoxy, -halogen,), or a mono or bicyclic heteroaryl group comprising 1, 2 or 3 nitrogen atoms, optionally substituted by -C1-6alkoxy, -C1-6alkyl, C1-6haloalkyl or =0; R2 represents H, benzoimidazolyl, benzothiazolyl, isoquinolinyl, or quinolinyl group or phenyl (said phenyl being optionally substituted by -NR3R4, -C1-4alkoxy, -C1-6alkyl, -CONR3R4, -SO2NR3R4, -NHCONR3R4, -NHCOC1-6alkyl, -C1-6haloalkyl, -OCH2O-, -phenoxy (wherein the phenyl moiety is optionally substituted by NH2 ), -C1-3alkyl, -C1-3alkoxy, -CF3, -5 membered heteroaryl group comprising one or two nitrogen atoms). R3 and R4 are independently selected from H, -C1-6alkyl, -C1-3alkylNR5R6; R5 and R6 are independently H or C1-3alkyl; or a salt, solvate, or physiologically functional derivative thereof.