853058-07-8Relevant articles and documents
APOPTOSIS SIGNAL-REGULATING KINASE 1 INHIBITORS AND METHODS OF USE THEREOF
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Page/Page column 83, (2018/12/02)
The present invention discloses compounds of Formula (I), or pharmaceutically acceptable salts, ester, stereoisomer, tautomer, solvate, hydrate, or combination thereof: which inhibit the Apoptosis signal-regulating kinase 1 (ASK-1), which associated with autoimmune disorders, neurodegenerative disorders, inflammatory diseases, chronic kidney disease, cardiovascular disease. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject suffering from ASK-1 related disease. The invention also relates to methods of treating an ASK-1 related disease in a subject by administering a pharmaceutical composition comprising the compounds of the present invention. The present invention specifically relates to methods of treating ASK-1 associated with hepatic steatosis, including non-alcoholic fatty liver disease (NAFLD) and non-alcohol steatohepatitis disease (NASH).
Synthesis and properties of oligocarboxamide molecular strands containing 1,8-naphthyridine and pyridine groups
Miyamoto, Hisakazu,Ikeuchi, Takahiro,Fujioka, Atsushi,Lehn, Jean-Marie,Ohba, Shigeru,Misaki, Yohji
, p. 2023 - 2029 (2008/01/27)
Oligocarboxamide molecular strands based on carboxamide between 1,8-naphthyridine and pyridine, pyridine and pyridine, 1,8-naphthyridine and benzene, and pyridine and benzene have been prepared. They have afforded various inclusion complexes with organic
Intramolecular versus intermolecular induction of helical handedness in pyridinedicarboxamide oligomers
Maurizot, Victor,Dolain, Christel,Huc, Ivan
, p. 1293 - 1301 (2007/10/03)
A new convergent synthetic scheme has been developed to prepare oligoamides of 2,6-diaminopyridine and 4-decyloxy-2,6-pyridinedicarboxylic acid. These compounds adopt stable single helical conformations in solution. NMR and circular dichroism studies show