HYDROXYETHYLAMINE DERIVATIVES FOR THE TREATMENT OF ALZHEIMER'S DISEASE
The present invention relates to novel hydroxyethylamine compounds of formula (I): (I) having Asp2 (-secretase, BACE1 or Memapsin) inhibitory activity, processes for their preparation, to compositions containing them and to their use in the treatment of diseases characterised by elevated-amyloid levels or-amyloid deposits, particularly Alzheimer's disease.
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Page 24-25
(2010/02/07)
Nitration of 2-Aryl-1,1-dichlorocyclopropanes
A series of 2-aryl-1,1-dichlorocyclopropanes were nitrated with a mixture of nitric acid and sulfuric acid.The results suggest that an electron-withdrawing group on the phenyl ring and gem-dihalogens on the cyclopropane ring are essential for isoxazole formation.
Lin, Shao-Tao,Yang, Fu-May
p. 1554 - 1564
(2007/10/03)
Amino-benzoic acids and derivatives, and methods of use
The present invention relates to compounds, compositions and methods for inhibiting nonenzymatic cross-linking (protein aging). Accordingly, a composition is disclosed which comprises an agent capable of inhibiting the formation of advanced glycosylation endproducts of target proteins by reacting with a carbonyl moiety of the early glycosylation product of such target proteins formed by their initial glycosylation. The method comprises contacting the target protein with the composition. Both industrial and therapeutic applications for the invention are envisioned, as food spoilage and animal protein aging can be treated.
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(2008/06/13)
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