85386-98-7

Basic information

• Product Name: 1-(3-IODO-PYRIDIN-2-YL)-PIPERAZINE
• Synonyms: 1-(3-IODO-PYRIDIN-2-YL)-PIPERAZINE;1-(3-Iodo-2-pyridyl)piperazine;1-(3-IODO-PYRIDIN-2-
• CAS NO: 85386-98-7
• Molecular Formula: C₉H₁₂IN₃
• Molecular Weight: 289.12
• Product Categories: pharmacetical;Halides;Pyridines
• Mol File: 85386-98-7.mol

Chemical Properties

• Melting Point: 63.1-67.8°C
• Boiling Point: 378.683 °C at 760 mmHg
• Flash Point: 182.821 °C
• Appearance: White powder
• Density: 1.671 g/cm³
• Storage Temp.: 2-8°C
• Sensitive: Moisture & Light Sensitive
• CAS DataBase Reference: 1-(3-IODO-PYRIDIN-2-YL)-PIPERAZINE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(3-IODO-PYRIDIN-2-YL)-PIPERAZINE(85386-98-7)
• EPA Substance Registry System: 1-(3-IODO-PYRIDIN-2-YL)-PIPERAZINE(85386-98-7)

Safety Data

• Hazard Codes: Xi
• HazardClass: IRRITANT
• Hazardous Substances Data: 85386-98-7(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
1-(3-IODO-PYRIDIN-2-YL)-PIPERAZINE is used as a building block for the synthesis of various organic compounds due to its unique structural properties, which facilitate the creation of new drugs and therapeutic agents.
Used in Neurological Applications:
1-(3-IODO-PYRIDIN-2-YL)-PIPERAZINE is used as a potential drug candidate for the treatment of certain neurological disorders and diseases, leveraging its unique chemical structure to target specific neurological conditions.
Used in Oncology:
In the field of oncology, 1-(3-IODO-PYRIDIN-2-YL)-PIPERAZINE is used as a potential drug candidate for cancer treatment, with ongoing research exploring its therapeutic potential against various types of cancer.
Used in Drug Discovery and Development:
1-(3-IODO-PYRIDIN-2-YL)-PIPERAZINE is utilized as a valuable tool in drug discovery and development, given its role in the synthesis of compounds with potential therapeutic uses in medical applications.

Upstream product

• 110-85-0 piperazine 
• 78607-36-0 2-chloro-3-iodopyridine 

Downstream Products

• 104813-87-8 1-(3-phenyl-2-pyridinyl)piperazine 

Relevant articles and documents

Design of potent, orally available antagonists of the transient receptor potential vanilloid 1. Structure-activity relationships of 2-piperazin-1-yl-1H- benzimidazoles

The vanilloid receptor-1 (VR1 or TRPV1) is a membrane-bound, nonselective cation channel that is predominantly expressed by peripheral neurons sensing painful stimuli. TRPV1 antagonists produce antihyperalgesic effects in animal models of inflammatory and neuropathic pain. Herein, we describe the synthesis and the structure-activity relationships of a series of 2-(4-pyridin-2- ylpiperazin-1-yl)-1H-benzo-[d]imidazoles as novel TRPV1 antagonists. Compound 46ad was among the most potent analogues in this series. This compound was orally bioavailable in rats and was efficacious in blocking capsaicin-induced flinch in rats in a dose-dependent manner. Compound 46ad also reversed thermal hyperalgesia in a model of inflammatory pain, which was induced by complete Freund's adjuvant (CFA).

4-(2-Pyridyl)piperazine-1-carboxamides: Potent vanilloid receptor 1 antagonists

A series of 4-(2-pyridyl)piperazine-1-carboxamide analogues based on the lead compound 1 was synthesized and evaluated for VR1 antagonist activity in capsaicin-induced (CAP) and pH (5.5)-induced (pH) FLIPR assays in a rat VR1-expressing HEK293 cell line. Potent VR1 antagonists were identified through SAR studies. From these studies, 18 was found to be very potent in the in vitro assay [IC50=4.8 nM (pH) and 35 nM (CAP)] and orally available in rat (F%=15.1).

Pyridinylpiperazines, a new class of selective α2-adrenoceptor antagonists

A series of 1-(2-pyridinyl)piperazine derivatives was synthesized and evaluated for adrenergic activity. In vitro activity was assessed through the antagonism of clonidine's effect in the rat, isolated, field-stimulated vas deferens and by the displacemen