- Synthesis of β-Amino Ketones using graphene oxide: a benign carbonaceous acid catalyst for Mannich reaction
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Abstract: Simple and easily preparable graphene oxide (GO) is used as a straightforward carbocatalyst for the synthesis of β-amino ketones via a 3-component Mannich reaction under mild condition. The native GO is acting as a carbonaceous solid Br?nsted acid catalyst without any special functionalization, yielding a spectrum of β-amino ketones under metal-free conditions. The present catalytic method offers a benign and simple procedure without any hazardous workup, and chromatographic purification resulted in an excellent yield of β-amino ketones. The catalyst has shown good sustainability up to 6 consecutive catalytic cycles without any significant loss in its activity. The stability of the recovered catalyst is proved by analytical techniques such as FT-IR, PXRD, SEM, and TEM. This mild solid-acid catalyst offers an alternative and sustainable approach to get synthetically essential β-amino ketones under greener conditions. Graphical abstract: [Figure not available: see fulltext.].
- Saravana Ganesan, Nagappan,Suresh, Palaniswamy
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p. 1197 - 1210
(2021/01/07)
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- Diaryliodonium salts as efficient Lewis acid catalysts for direct three component Mannich reactions
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Diaryliodonium(iii) salts, as highly active and versatile Lewis acid catalysts for the direct three component Mannich reaction under solvent free conditions, have been investigated. The Mannich products were isolated in good to excellent yields in a very clean manner. Additionally, the catalyst could be recycled without significant loss of its catalytic activity. This journal is
- Zhang, Yanxia,Han, Jianwei,Liu, Zhen-Jiang
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p. 25485 - 25488
(2015/03/30)
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- Synthesis of unsymmetrical β-arylaminoketones
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Azomethines derived from aniline were condensed with acetophenone derivatives to obtain new unsymmetrical β-arylaminoketones.
- Kozlov,Basalaeva
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p. 926 - 932
(2007/10/03)
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- The Mannich reaction between aromatic ketones, aromatic aldehydes and aromatic amines
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The acid-catalyzed Mannich reaction of acetophenones with benzaldehyde derivatives and aromatic amines gives 1,3-diaryl-3-(arylamino)propanones in high yield.
- Lin,Huangshu,Junhua,Xiujuan
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p. 717 - 718
(2007/10/02)
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