- A NEW CONVENIENT SYNTHESIS OF α-ARYLPROPIONIC ACID ESTERS AND α-ARYLPROPIONITRILES
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Various types of α-arylpropionic acid esters were effectively obtained by the coupling reaction of aryl Grignard reagents and α-bromopropionic acid esters in the presence of nickel catalysts. α-Arylpropionitriles, precursors of α-arylpropionic acids, were also synthesized by the reaction of α-methanesulfonyloxypropionitrile and arylcopper reagents prepared from equimolar amount of arylmagnesium halides and copper(I) bromide.
- Amano, Takehiro,Yoshikawa, Kensei,Sano, Tatsuhiko,Ohuchi, Yutaka,Shiono, Manzo,et al.
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p. 499 - 508
(2007/10/02)
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- Process for producing α-arylalkanoic acid ester
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A process for producing an α-arylalkanoic acid ester represented by the general formula STR1 wherein Ar represents an aryl group which may optionally be substituted, and R1 and R2, independently from each other, represent a lower alkyl group, which comprises reacting a Grignard reagent prepared from an aryl halide of the general formula wherein Ar is as defined above and X1 represents a halogen atom, and magnesium, with an α-haloalkanoic acid ester of the general formula STR2 wherein R1 and R2 are as defined above, and X2 represents a halogen atom, said reaction of the Grignard reagent with the α-haloalkanoic acid ester of general formula (III) being carried out in the presence of a nickel compound.
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- Esters of the carboxylic acid
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A novel carboxylic acid ester having the following general formula STR1 wherein R is alkoxyalkyl having 2 to 6 carbon atoms, cycloalkyl having 5 or 6 carbon atoms, tetrahydrofurfuryl, or alkyl having 1 to 6 carbon atoms optionally substituted with 1 or 2
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