854778-31-7

Basic information

• Product Name: 4-FLUORO-3-METHOXYPHENYLBORONIC ACID
• Synonyms: Boronicacid, (4-fluoro-3-methoxyphenyl)- (9CI);5-Borono-2-fluoroanisole;4-Fluoro-3-Methoxyphenylboronic Acid (contains varying aMounts of Anhydride);4-Fluoro-5-methoxyphenylboronic acid;4-Fluoro-3-Methoxyphenylboronic;4-FLUORO-3-METHOXYBENZENEBORONIC ACID;4-FLUORO-3-METHOXYPHENYLBORONIC ACID;4-Fluoro-3-methoxybenzeneboronic acid 98%
• CAS NO: 854778-31-7
• Molecular Formula: C₇H₈BFO₃
• Molecular Weight: 169.95
• Product Categories: blocks;BoronicAcids;FluoroCompounds
• Mol File: 854778-31-7.mol

Chemical Properties

• Melting Point: 189-191
• Boiling Point: 318.1 °C at 760 mmHg
• Flash Point: 146.2 °C
• Appearance: /
• Density: 1.26 g/cm³
• Vapor Pressure: 0.000155mmHg at 25°C
• Refractive Index: 1.503
• Storage Temp.: Keep Cold
• Solubility: soluble in Methanol
• PKA: 8.19±0.10(Predicted)
• CAS DataBase Reference: 4-FLUORO-3-METHOXYPHENYLBORONIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 4-FLUORO-3-METHOXYPHENYLBORONIC ACID(854778-31-7)
• EPA Substance Registry System: 4-FLUORO-3-METHOXYPHENYLBORONIC ACID(854778-31-7)

Safety Data

• Hazard Codes: Xi
• Statements: 36
• Safety Statements: 26
• HazardClass: IRRITANT
• Hazardous Substances Data: 854778-31-7(Hazardous Substances Data)

Usage

Uses

suzuki reaction

InChI:InChI=1/C7H8BFO3/c1-12-7-4-5(8(10)11)2-3-6(7)9/h2-4,10-11H,1H3

Upstream product

• 1033691-66-5 C₇H₆BF₄O^(1-) 
• 103291-07-2 4-bromo-1-fluoro-2-methoxy-benzene 

Downstream Products

• 1430419-24-1 2,5-bis(4-fluoro-3-hydroxyphenyl)thiophene 
• 1430419-16-1 2,5-bis(4-fluoro-3-methoxyphenyl)thiophene 
• 1396242-61-7 5-(4-fluoro-3-methoxyphenyl)-N-(3-methoxyphenyl)-N-methylthiophene-2-carboxamide 
• 1416217-80-5 1-(1-benzyl-2-ethyl-4-nitro-1H-imidazol-5-yl)-4-(4'-fluoro-3'-methoxy-[1,1'-biphenyl]-4-yl)piperazine 
• 1300584-59-1 2-(1-(4-amino-3-(4-fluoro-3-hydroxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)ethyl)-3-(3-fluorophenyl)-4H-chromen-4-one 
• 1300584-56-8 2-(1-(4-amino-3-(4-fluoro-3-methoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)ethyl)-3-(3-fluorophenyl)-4H-chromen-4-one 
• 1255940-16-9 [5-(4-fluoro-3-methoxyphenyl)-2-thienyl](3-methoxyphenyl)methanone 
• 960231-73-6 2-(3-Carbamoylphenylamino)-2-(4-fluoro-3-methoxyphenyl)acetic acid 
• 1227633-11-5 4-fluoro-2-iodo-5-methoxyphenylboronic acid 
• 1193525-60-8 2-(4-fluoro-3-methoxyphenyl)-5-(4-methoxyphenyl)thiophene 
• 1193525-70-0 2-(3-fluoro-4-methoxyphenyl)-5-(4-fluoro-3-methoxyphenyl)thiophene 
• 1134915-74-4 5-{2-[2-chloro-4-(4-fluoro-3-methoxy-phenoxy)-phenyl]-1-hydroxy-1-trifluoromethyl-propyl}-1-methyl-1H-pyridin-2-one 
• 1036390-11-0 C₁₇H₁₅FN₂O₄ 
• 1036390-13-2 C₁₈H₁₅FN₂O₄ 

Relevant articles and documents

BENZAMIDE FACTOR VIIA INHIBITORS USEFUL AS ANTICOAGULANTS

The present invention provides novel benzamide derivatives of Formula (I): or a stereoisomer, tautomer, pharmaceutically acceptable salt, solvate, or prodrug thereof, wherein the variables A, W, Y, Z, R8, and R9 are as defined herein. These compounds are selective inhibitors of factor VIIa which can be used as medicaments.

Substituent effects on aryltrifluoroborate solvolysis in water: Implications for Suzuki-Miyaura coupling and the design of stable 18F-labeled aryltrifluoroborates for use in PET imaging

(Chemical Equation Presented) Whereas electron withdrawing substituents retard the rate of aryltrifluoroborate solvolysis, electron-donating groups enhance it. Herein is presented a Hammett analysis of the solvolytic lability of aryltrifluoroborates where log(Ksolv) values correlate to a values with a ρ value of approximately -1. This work provides a predictable rubric for tuning the reactivity of boron for several uses including 18F-labeled PET reagents and has mechanistic implications for ArBF3-enhanced ligandless metal-mediated cross coupling reactions with aryltrifluoroborates.

Phenylglycinamide and pyridylglycinamide derivatives useful as anticoagulants

The present invention provides novel phenylglycinamide derivatives of Formula (I) or (IV): or a stereoisomer, tautomer, pharmaceutically acceptable salt, solvate, or prodrug thereof, wherein the variables W, W1, Y, Z, R7, R8, R9, and R11 are as defined herein. These compounds are selective inhibitors of factor VIIa which can be used as medicaments.

PHENYLGLYCINAMIDE DERIVATIVES USEFUL AS ANTICOAGULANTS

The present invention relates generally to phenylglycinamide derivatives that inhibit serine proteases. In particular it is directed to novel phenylglycinamide derivatives, and analogues thereof, which are useful as selective inhibitors of serine protease enzymes of the coagulation cascade; for example thrombin, factor VIIa, factor Xa, factor XIa, factor IXa, and/or plasma kallikrein. In particular, it relates to compounds that are factor VIIa inhibitors. This invention also relates to pharmaceutical compositions comprising these compounds and methods of using the same.