Chiral guanidine catalyzed acylative kinetic resolution of racemic 2-bromo-1-arylethanols
In this study, chiral guanidine catalyzed acylative kinetic resolution of racemic 2-bromo-1-arylethanols was achieved with high selectivity. Irrespective of the electronic nature and the substitution patterns on the aromatic rings, a variety of substrates were suitable for this reaction. The branched acyl component was considered to be optimal for obtaining high s-values. The transition state of the reaction was proposed based on the absolute configuration of the obtained product.
Sawada, Erika,Nakata, Kenya
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p. 371 - 373
(2021/03/16)
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