85554-24-1Relevant articles and documents
Synthetic method of xanthene-9-formic acid
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Paragraph 0035; 0040; 0041; 0044; 0049; 0050, (2017/12/09)
The invention discloses a synthetic method of xanthene-9-formic acid, which belongs to the field of chemical synthesis. The method comprises the following steps: xanthone is taken as a raw material, then is reduced to xanthydrol under alkaline condition by zinc dust, then the xanthydrol is subjected to a halogenated reaction to obtain the halogenated xanthene, then under effect of a catalyst, a cyanidation reaction is generated to obtain 9-cyan xanthene, through alkali hydrolysis, organic impurity is removed through extraction of an organic solvent, a xanthene-9-formate aqueous solution is obtained, and a xanthene-9-formic acid product is obtained through a neutralization reaction. The method has the advantages of simple operation and safe technology, the xanthene-9-formic acid with high purity is obtained without refining, and the method is easy and effective for industrial production.
MANUFACTURING METHOD OF 9-CYANO XANTHENE
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Paragraph 0033, (2017/04/07)
PROBLEM TO BE SOLVED: To provide a method manufacturing 9-cyano xanthene which is an extremely important compound as an intermediate product of propantheline acid bromide used as a digestive medicine widely from xanthone by a single stage reaction with a high yield and a high selectivity without using dangerous chemical reagents. SOLUTION: With a high yield and a high selectivity, 9-cyano xanthene is manufactured by contacting xanthone and sulfonyl methyl isocyanide derivative in organic solvent such as alcohol of a carbon number 1-4 and/or ether of a carbon number 2-8 under a presence of base such as alkali metal alkoxide and/or diazabicyclo compound. SELECTED DRAWING: None COPYRIGHT: (C)2016,JPOandINPIT
Selective serotonin receptor antagonists and therapeutic applications thereof
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Page 14-15, (2010/02/05)
Spiro[9,10-dihydroanthracene]-9,3′-pyrrolidine (SPAN) and derivatives thereof are provided as selective serotonin receptor antagonists. The compounds are selective, high affinity antagonists of 5-HT2 serotonin receptors. The compounds are useful as antidepressant and antianxiety agents.
Cyclic diphenylacetonitriles as stabilizers
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, (2008/06/13)
Compounds of the formula I STR1 in which the general symbols are as defined in claim 1, as stabilizers for organic materials against thermal, oxidative or light-induced degradation are described.
New Triazine Derivatives as Potent Modulators of Multidrug Resistance
Dhainaut, Alain,Regnier, Gilbert,Atassi, Ghanem,Pierre, Alain,Leonce, Stephane,et al.
, p. 2481 - 2496 (2007/10/02)
A series of 70 triazine derivatives have been synthesized and tested for their capacity to modulate multidrug resistance (MDR) in DC-3F/AD and KB-A1 tumor cells in vitro, in comparison with verapamil (VRP), a calcium channel antagonist currently used in therapy as an antihypertensive drug, which also shows MDR modulating activity.Among the 12 selected compounds, 16 (S9788) showed high MDR reversing properties in vitro (300- and 6-fold VRP at 5μM in DC-3F/AD and KB-A1 cells, respectively) and induced a strong accumulation of adriamycin.The relationship between the increase of ADR accumulation and the fold reversal induced by these compounds and their lack of effects on the sensitive DC-3F cells suggest that they act mainly by inhibiting the P-glycoprotein (Pgp) catalyzed efflux of cytotoxic agents, as already described for a majority of MDR modulators.In vivo, in association with the antitumor drug vincristine (0.25 mg/kg), 16 (100 mg/kg) increased the T/C by 39percent in mice bearing the resistant tumor cell line P388/VCR.According to these interesting properties, 16 was selected for a clinical development because it is more bioavailable than 34, even though it was less active.
Contrasting Photosolvolytic Reactivities of 9-Fluorenol vs 5-Suberenol Derivatives. Enhanced Rate of Formation of Cyclically Conjugated Four ? Carbocations in the Excited State
Wan, Peter,Krogh, Erik
, p. 4887 - 4895 (2007/10/02)
The photosolvolysis of 9-fluorenol (1) and several of its derivatives, as well as related systems, has been studied in aqueous methanol and acetonitrile solutions.The primary aim of this study was to examine the effect of the internal cyclic array (ICA) of these compounds in promoting photosolvolysis with respect to the number of ? electrons available in the ICA.It was observed that 9-fluorenol derivatives photosolvolyze much more efficiently than any of the related systems studied in this work.In contrast, ground-state 9-fluorenol derivatives are the least reactive systems with respect to solvolysis.Quantum yields for methyl ether formation for photosolvolysis in 50percent MeOH-H2O are reported for 1-3.Rate constants for solvent-assisted photodehydroxylation (ks) are calculated on the basis of the proposed mechanism of heterolytic C-OH bond rupture in the primary photochemical step and are in the range (1.3-1.6)x1E10 s-1 for 1-3.
Steric, Conformational, and Electronic Effects as Revealed by Acidities of Substituted Xanthenes and Reactions of Substituted Xanthenyl and Related Carbanions with Benzyl Chloride
Bordwell, Frederick G.,Hughes, David L.
, p. 2216 - 2222 (2007/10/02)
Equilibrium acidities in Me2SO solution for 9-substituted xanthenes (9-G-XnH) with G = H, CN, PhS, PhSO2, CO2Me, and Ar are reported.Comparison of these acidities with those of related compounds, GCH2CN, 9-G-FlH (9-substituted fluorenes), and GCHPh2, show
