- Facile one-pot synthesis of [1,2,3]triazolo[1,5-a]pyridines from 2-acylpyridines by copper(II)-catalyzed oxidative N-N bond formation
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An efficient and simple method for the synthesis of various [1,2,3]triazolo[1,5-a]pyridines has been established. The method involves a copper(II)-catalyzed oxidative N-N bond formation that uses atmospheric oxygen as the terminal oxidant following hydrazonation in one pot. The use of ethyl acetate as the solvent dramatically promotes the oxidative N-N bond-formation reaction and enables the application of oxidative cyclization in the efficient one-pot reaction. A mechanism for the reaction was proposed on the basis of the results of a spectroscopic study. In the same pot: [1,2,3]Triazolo[1,5-a] pyridines are synthesized from the corresponding 2-acylpyridines by a one-pot method, consisting of hydrazonation followed by oxidative cyclization through copper(II)-catalyzed N-N bond formation (see scheme).
- Hirayama, Tasuku,Ueda, Satoshi,Okada, Takahiro,Tsurue, Norihiko,Okuda, Kensuke,Nagasawa, Hideko
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supporting information
p. 4156 - 4162
(2014/04/17)
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- Ruthenium catalyzed hydrohydroxyalkylation of isoprene with heteroaromatic secondary alcohols: Isolation and reversible formation of the putative metallacycle intermediate
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Heteroaromatic secondary alcohols react with isoprene to form products of hydrohydroxyalkylation in the presence of ruthenium(0) catalysts generated from Ru3(CO)12 and tricyclohexylphosphine, enabling direct conversion of secondary to tertiary alcohols in the absence of premetalated reagents or stoichiometric byproducts. The putative oxaruthenacycle intermediate has been isolated and characterized, and reversible metallacycle formation has been demonstrated.
- Park, Boyoung Y.,Montgomery, T. Patrick,Garza, Victoria J.,Krische, Michael J.
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supporting information
p. 16320 - 16323
(2013/12/04)
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- FUSED RING HETEROCYCLE KINASE MODULATORS
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The present invention provides fused ring heterocycles as kinase modulators, pharmaceutical compositions containing these modulators, and methods of using these modulators to treat diseases mediated by kinase activity.
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Page/Page column 75
(2008/12/04)
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- Biomimetic trifunctional organocatalyst showing a great acceleration for the transesterification between vinyl ester and alcohol
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Trifunctional organocatalysts 1a and 1b mimicking the active site of serine hydrolases showed high catalytic activity with up to a 3 700 000-fold acceleration for the acyl-transfer reactions from vinyl trifluoroacetate to alcohol. The Royal Society of Chemistry.
- Ema, Tadashi,Tanida, Daisuke,Matsukawa, Tatsuya,Sakai, Takashi
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p. 957 - 959
(2008/09/21)
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