Substituted 1-azaadamantanes of type 14 are facilely prepared from the six-membered rings 2.Functionalized derivatives 2 of cyclohexane are easily synthesized from α,β-unsaturated ketones and dimethyl malonate or by similar procedures.With hexamethylenetetramine as partner the azatricyclic products 14 are formed in one step from 2.The Mannich-type mechanism of the key reaction is discussed, and the 1H NMR data are analyzed.
Risch, Nikolaus
p. 4073 - 4085
(2007/10/02)
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