- Practical synthesis of polysubstituted imidazoles via iodine- Catalyzed aerobic oxidative cyclization of aryl ketones and benzylamines
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A practical synthetic method for polysubstituted imidazoles via iodine-catalyzed aerobic oxidative cyclization of aryl ketones and benzylamines has been developed. It was found to tolerate a broad range of substrates to prepare polysubstituted imidazole derivatives in a one-pot manner, and thus importantly allowed product diversity for imidazole chemistry. Additionally, the resultant 1,2,4-trisubstituted imidazoles could be conveniently transformed to functionalized 1,2,4,5-tetrasubstituted imidazoles via electrophilic substitution or direct C-H functionalization, or 2,4-diaryl-1H-imidazoles by debenzylation reaction, which further indicates potential applications of this method in synthetic and pharmaceutical chemistry. Copyright
- Huang, Huawen,Ji, Xiaochen,Wu, Wanqing,Jiang, Huanfeng
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p. 170 - 180
(2013/03/13)
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- Neurokinin-3 receptor modulators: diaryl imidazole derivatives
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The invention relates to compounds of general Formula I: wherein the variables are as defined herein. Also provided are pharmaceutical compositions comprising such compounds, and methods for treating patients suffering from a disorder responsive to neurok
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Page/Page column 20
(2010/02/12)
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