857284-25-4

Basic information

• Product Name: [2-[4-(TRIFLUOROMETHYL)PHENYL]-1,3-THIAZOL-4-YL]METHANOL
• Synonyms: [2-[4-(TRIFLUOROMETHYL)PHENYL]-1,3-THIAZOL-4-YL]METHANOL
• CAS NO: 857284-25-4
• Molecular Formula: C₁₁H₈F₃NOS
• Molecular Weight: 259.25
• Mol File: 857284-25-4.mol

Chemical Properties

• Melting Point: 107 °C
• Boiling Point: 363.6°C at 760 mmHg
• Flash Point: 173.7°C
• Appearance: /
• Density: 1.403g/cm³
• Vapor Pressure: 6.35E-06mmHg at 25°C
• Refractive Index: 1.548
• CAS DataBase Reference: [2-[4-(TRIFLUOROMETHYL)PHENYL]-1,3-THIAZOL-4-YL]METHANOL(CAS DataBase Reference)
• NIST Chemistry Reference: [2-[4-(TRIFLUOROMETHYL)PHENYL]-1,3-THIAZOL-4-YL]METHANOL(857284-25-4)
• EPA Substance Registry System: [2-[4-(TRIFLUOROMETHYL)PHENYL]-1,3-THIAZOL-4-YL]METHANOL(857284-25-4)

Safety Data

• Hazardous Substances Data: 857284-25-4(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
[2-[4-(TRIFLUOROMETHYL)PHENYL]-1,3-THIAZOL-4-YL]METHANOL is used as a building block for the development of new drug candidates due to its unique structure and properties. [2-[4-(TRIFLUOROMETHYL)PHENYL]-1,3-THIAZOL-4-YL]METHANOL's trifluoromethyl group can improve the pharmacokinetic properties of drug molecules, while the thiazole moiety exhibits a broad spectrum of biological activities, making it a valuable component in the creation of novel pharmaceuticals.
Used in Agrochemical Industry:
In the agrochemical industry, [2-[4-(TRIFLUOROMETHYL)PHENYL]-1,3-THIAZOL-4-YL]METHANOL may be utilized as a starting material or intermediate for the synthesis of various agrochemical products. Its unique structure and properties can potentially contribute to the development of new pesticides, herbicides, or other agrochemicals with improved efficacy and selectivity.
Further investigation and research into the properties and potential applications of [2-[4-(TRIFLUOROMETHYL)PHENYL]-1,3-THIAZOL-4-YL]METHANOL are warranted to fully understand its capabilities and maximize its utility in these industries.

InChI:InChI=1/C11H8F3NOS/c12-11(13,14)8-3-1-7(2-4-8)10-15-9(5-16)6-17-10/h1-4,6,16H,5H2

Upstream product

• 128796-39-4 4-trifluoromethylphenylboronic acid 
• 72505-21-6 4-trifluoromethylbenzthioamide 
• 1315510-13-4 methyl 2-(4-trifluoromethylphenyl)thiazole-4-carboxylate 
• 175204-88-3 2-[4-(trifluoromethyl)phenyl]thiazole-4-carboxylic acid ethyl ester 

Downstream Products

• 119514-24-8 2-(4-(trifluoromethyl)phenyl)thiazole 
• 952710-11-1 4-bromomethyl-2-(4-trifluoromethyl-phenyl)-thiazole 

Relevant articles and documents

Design, synthesis and biological evaluation of novel thiazole-derivatives as mitochondrial targeting inhibitors of cancer cells

Mitochondria are pivotal energy production sources for cells to maintain necessary metabolism activities. Targeting dysfunctional mitochondrial features has been a hotspot for mitochondrial-related disease researches. Investigation with cancerous mitochondrial metabolism is a continuing concern within tumor therapy. Herein, we set out to assess the anti-cancer activities of a novel family of TPP-thiazole derivatives based on our earlier research on mitochondrial targeting agents. Specifically, we designed and synthesized a series of TPP-thiazole derivatives and revealed by the MTT assay that most synthesized compounds effectively inhibited three cancer cell lines (HeLa, PC3 and MCF-7). After structure modifications, we explored the SAR relationships and identified the most promising compound R13 (IC50 of 5.52 μM) for further investigation. In the meantime, we performed ATP production assay to assess the selected compounds inhibitory effect on HeLa cells energy production. The results displayed the test compounds significantly restrained ATP production of cancer cells. Overall, we have designed and synthesized a series of compounds which exhibited significant cytotoxicity against cancer cells and effectively inhibited mitochondrial energy production.

Metal-Free Aerobic Oxidative Selective C-C Bond Cleavage in Heteroaryl-Containing Primary and Secondary Alcohols

A transition-metal-free aerobic oxidative selective C-C bond-cleavage reaction in primary and secondary heteroaryl alcohols is reported. This reaction was highly efficient and tolerated various heteroaryl alcohols, generating a carboxylic acid derivative and a neutral heteroaromatic compound. Experimental studies combined with density functional theory calculations revealed the mechanism underlying the selective C-C bond cleavage. This strategy also provides an alternative simple approach to carboxylation reaction.

Imidazo ring PAR4 antagonist and medical applications thereof

The invention relates to an imidazo ring compound represented by formula (I) or formula (II), or a pharmaceutically acceptable salt or ester or solvate thereof. The compound disclosed by the inventioncan be used for preparing medicines for preventing or treating thromboembolic diseases.

BENZOAZEPIN-OXY-ACETIC ACID DERIVATIVES AS PPAR-DELTA AGONISTS USED FOR THE INCREASE OF HDL-C, LOWER LDL-C AND LOWER CHOLESTEROL

The invention is directed to compounds of Formula (I) useful as PPAR agonists. Pharmaceutical compositions and methods of treating one or more conditions including, but not limited to, diabetes, nephropathy, neuropathy, retinopathy, polycystic ovary syndr