Does targeting Arg98 of FimH lead to high affinity antagonists?
Bacterial resistance has become an important challenge in the treatment of urinary tract infections. The underlying resistance mechanisms can most likely be circumvented with an antiadhesive approach, antagonizing the lectin FimH located at the tip of fim
Toma?i?, Tihomir,Rabbani, Said,Jakob, Roman P.,Reisner, Andreas,Jakopin, ?iga,Maier, Timm,Ernst, Beat,Anderluh, Marko
(2020/12/21)
Solid-Supported Iodonium Salts for Fluorinations
Solid-supported iodonium salt precursors have been prepared and used for the production of fluoroarenes. The importance of the resin functionality for the attachment of the iodonium salt moieties has been demonstrated. Furthermore, the production of new i
Edwards, Richard,De Vries, Wilke,Westwell, Andrew D.,Daniels, Stephen,Wirth, Thomas
supporting information
p. 6909 - 6916
(2015/11/02)
Low temperature enantiotropic nematic phases from V-shaped, shape-persistent molecules
A series of V-shaped, shape-persistent thiadiazole nematogens, based on an oligo(phenylene ethynylene) scaffold with ester groups connected via alkyloxy spacers, was efficiently prepared by a two-step procedure. Phase engineering results in an optimum of
Lehmann, Matthias,Seltmann, Jens
supporting information; experimental part
(2010/04/22)
RADICAL TRAP IN FLUORIDATION OF IODONIUM SALT
Decomposition of iodonium salts by a free radical process has been identified as a significant factor in the observed yield variability of fluoridation reactions using said iodonium salts. Accordingly, the inclusion of a free radical trap in the reaction mixture blocks the radical chain decomposition pathway for iodonium salts such that only the reaction leading to fluoridation can occur and the yield of aryl fluoride becomes high and reproducible. The reaction may also be carried out on solid phase. In both the solution and the solid phase the preferred method of the present invention is radiofluoridation.
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Page/Page column 19
(2008/06/13)
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