857650-89-6Relevant articles and documents
A METHOD OF TREATING LIVER FIBROSIS
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, (2012/09/11)
The present invention relates to a method of treating hepatis C and/or liver fibroisis with 3-cycloalkylaminopyrrolidine derivatives of the present invention
Discovery of INCB8761/PF-4136309, a potent, selective, and orally bioavailable CCR2 antagonist
Xue, Chu-Biao,Wang, Anlai,Han, Qi,Zhang, Yingxin,Cao, Ganfeng,Feng, Hao,Huang, Taisheng,Zheng, Changsheng,Xia, Michael,Zhang, Ke,Kong, Lingquan,Glenn, Joseph,Anand, Rajan,Meloni, David,Robinson,Shao, Lixin,Storace, Lou,Li, Mei,Hughes, Robert O.,Devraj, Rajesh,Morton, Philip A.,Rogier, D. Joseph,Covington, Maryanne,Scherle, Peggy,Diamond, Sharon,Emm, Tom,Yeleswaram, Swamy,Contel, Nancy,Vaddi, Kris,Newton, Robert,Hollis, Greg,Metcalf, Brian
supporting information; experimental part, p. 913 - 918 (2012/02/13)
We report the discovery of a new (S)-3-aminopyrrolidine series of CCR2 antagonists. Structure-activity relationship studies on this new series led to the identification of 17 (INCB8761/PF-4136309) that exhibited potent CCR2 antagonistic activity, high sel
3-Cycloalkylaminopyrrolidine derivatives as modulators of chemokine receptors
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Page/Page column 21, (2008/06/13)
The present invention relates to 3-cycloalkylaminopyrrolidine derivatives of the formula I: (wherein R1, R2, R3, R4, R5, R6, R7, X, Y and Z are as defined herein) which are useful as modulators of chemokine receptor activity. In particular, these compounds are useful as modulators of chemokine receptors and more specifically as modulators of the CCR2 and/or CCR5 receptor. The compounds and compositions of the invention may bind to chemokine receptors, e.g., the CCR2 and/or CCR5 chemokine receptors, and are useful for treating diseases associated with chemokine, e.g., CCR2 and/or CCR5, activity, such as atherosclerosis, restenosis, lupus, organ transplant rejection and rheumatoid arthritis.