CARBON-CARBON BOND FORMATION UNDER MILD CONDITIONS VIA TANDEM CATIONIC AZA-COPE REARRANGEMENT-MANNICH REACTIONS. A CONVENIENT SYNTHESIS OF POLYSUBSTITUTED PYRROLIDINES.
The reaction of aldehydes (or ketones) with 2-alkoxy(or hydroxy)-3-alkenamines achieves a general and high-yielding synthesis of polysubstituted 3-acylpyrrolidines (eq 5-9). This tandem cationic aza-Cope rearrangement-Mannich cyclization reaction (eq 1) o
Overman,Kakimoto,Okazaki,Meier G. Patrick
p. 6622 - 6629
(2007/10/02)
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