Benzylation of nitroalkanes using copper-catalyzed thermal redox catalysis: Toward the facile C-alkylation of nitroalkanes
The C-alkylation of nitroalkanes under mild conditions has been a significant challenge in organic synthesis for more than a century. Herein we report a simple Cu(I) catalyst, generated in situ, that is highly effective for C-benzylation of nitroalkanes using abundant benzyl bromides and related heteroaromatic compounds. This process, which we believe proceeds via a thermal redox mechanism, allows access to a variety of complex nitroalkanes under mild reaction conditions and represents the first step toward the development of a general catalytic system for the alkylation of nitroalkanes.
Gildner, Peter G.,Gietter, Amber A. S.,Cui, Di,Watson, Donald A.
supporting information; experimental part
p. 9942 - 9945
(2012/08/07)
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