85888-81-9

Basic information

• Product Name: 2-(Chloromethyl)benzoic acid
• Synonyms: RARECHEM AL BO 1528;2-(CHLOROMETHYL)BENZOIC ACID;o-Chloromethylbenzoic acid;α-Chloro-o-toluic acid;2-(Chloromethyl)benzoic acid >=97.0% (GC)
• CAS NO: 85888-81-9
• Molecular Formula: C₈H₇ClO₂
• Molecular Weight: 170.59
• Product Categories: Organic acids
• Mol File: 85888-81-9.mol

Chemical Properties

• Melting Point: 135-135.5 °C
• Boiling Point: 305.7 °C at 760 mmHg
• Flash Point: 138.7 °C
• Appearance: flaky crystal
• Density: 1.315 g/cm³
• Vapor Pressure: 0.000353mmHg at 25°C
• Refractive Index: 1.576
• Storage Temp.: ?20°C
• PKA: 3.73±0.36(Predicted)
• BRN: 1940772
• CAS DataBase Reference: 2-(Chloromethyl)benzoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(Chloromethyl)benzoic acid(85888-81-9)
• EPA Substance Registry System: 2-(Chloromethyl)benzoic acid(85888-81-9)

Safety Data

• Hazard Codes: C
• Statements: 22-34
• Safety Statements: 26-36/37/39-45
• RIDADR: 3261
• WGK Germany: 3
• HazardClass: 8
• PackingGroup: Ⅲ
• Hazardous Substances Data: 85888-81-9(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
2-(Chloromethyl)benzoic acid serves as a key intermediate in the synthesis of various pharmaceuticals, contributing to the development of new drugs and therapeutic agents. Its unique chemical structure allows for versatile reactions and modifications, enhancing the medicinal properties of the final products.
Used in Agrochemical Industry:
In the agrochemical sector, 2-(Chloromethyl)benzoic acid is employed as a building block for the synthesis of pesticides and other agrochemicals. Its reactivity and functional groups enable the creation of compounds with targeted pest control properties, contributing to agricultural productivity and crop protection.
Used in Dye and Fragrance Industry:
2-(Chloromethyl)benzoic acid is utilized as an intermediate in the production of dyes and fragrances, where its chemical properties facilitate the creation of a wide range of colorants and aromatic compounds. This contributes to the development of various products in the textile, cosmetic, and perfume industries.
Safety Precautions:
Given the hazardous nature of 2-(Chloromethyl)benzoic acid, it is essential to follow safety precautions when handling this chemical. This includes wearing appropriate personal protective equipment, such as gloves, goggles, and masks, to prevent ingestion, inhalation, or skin and eye contact. Proper storage and disposal methods should also be adhered to, minimizing the risk of accidental exposure or environmental contamination.

InChI:InChI=1/C8H7ClO2/c9-5-6-3-1-2-4-7(6)8(10)11/h1-4H,5H2,(H,10,11)

Upstream product

• 42908-86-1 2-Chloromethylbenzoyl chloride 
• 118-90-1 ortho-methylbenzoic acid 

Downstream Products

• 371979-24-7 (2R,4R)-4-tert-Butoxycarbonylamino-1-(2-carboxy-benzyl)-pyrrolidine-2,4-dicarboxylic acid dimethyl ester 
• 879213-64-6 2-chloromethyl-N-(4-morpholin-4-yl-phenyl)-benzamide 
• 879213-56-6 2-chloromethyl-N-(4-isopropyl-phenyl)-benzamide 
• 879213-54-4 N-(4-tert-butyl-phenyl)-2-chloromethyl-benzamide 
• 879213-68-0 2-chloromethyl-N-(2-fluoro-4-methyl-phenyl)-benzamide 
• 879213-52-2 2-chloromethyl-N-(4-chloro-phenyl)-benzamide 
• 879213-69-1 N-benzo[1,3]dioxol-5-yl-2-chloromethyl-benzamide 
• 879213-60-2 2-chloromethyl-N-m-tolyl-benzamide 
• 879213-66-8 2-chloromethyl-N-(3,4-dichloro-phenyl)-benzamide 
• 879213-67-9 2-chloromethyl-N-(4-chloro-3-trifluoromethyl-phenyl)-benzamide 
• 879213-62-4 2-chloromethyl-N-o-tolyl-benzamide 
• 879213-70-4 N-(4-bromo-phenyl)-2-chloromethyl-benzamide 

Relevant articles and documents

Production method of methyl o-formate benzyl sulfonamide

The invention belongs to the technical field of pesticide intermediates, and particularly relates to a production method of methyl o-formate benzyl sulfonamide. The production method comprises steps:reacting o-methylbenzoic acid with sulfuryl chloride to obtain o-chloromethylbenzoic acid; reacting o-chloromethylbenzoic acid with methanol to obtain o-chloromethyl methyl benzoate; reacting o-chloromethyl methyl benzoate with sodium thiosulfate to obtain methyl o-formate benzyl mercaptan, reacting methyl o-formate benzyl mercaptan with chlorine to obtain methyl o-formate benzyl sulfonyl chloride, and reacting methyl o-formate benzyl sulfonyl chloride with ammonia gas to obtain methyl o-formate benzyl sulfonamide. According to the method, polychlorinated side reactions in the production process are reduced, the yield is increased, the tar yield is reduced, and the problems of low yield and high cost in the production process are solved.