- INTEGRIN ANTAGONISTS
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The present disclosure provides pharmaceutical agents, including those of the formula:(I) wherein the variables are defined herein. Also provided are pharmaceutical compositions, kits and articles of manufacture comprising such pharmaceutical agents. Meth
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Page/Page column 109-110
(2018/08/03)
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- Nucleophilic Amination of Methoxy Arenes Promoted by a Sodium Hydride/Iodide Composite
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A method for the nucleophilic amination of methoxy arenes was established by using sodium hydride (NaH) in the presence of lithium iodide (LiI). This method offers an efficient route to benzannulated nitrogen heterocycles. Mechanistic studies showed that the reaction proceeds through an unusual concerted nucleophilic aromatic substitution.
- Kaga, Atsushi,Hayashi, Hirohito,Hakamata, Hiroyuki,Oi, Miku,Uchiyama, Masanobu,Takita, Ryo,Chiba, Shunsuke
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supporting information
p. 11807 - 11811
(2017/09/20)
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- Distyrylbenzene-based segmented conjugated polymers: Synthesis, thin film morphology and chemosensing of hydrophobic and hydrophilic nitroaromatics in aqueous media
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Two new segmented conjugated polymers bearing distyrylbenzene chromophoric units and their model compounds were synthesized. The tendency of the model compounds to form H- and J-type aggregates in the amorphous matrix was greatly diminished by the twisted polymeric architecture. Fluorescence anisotropy measurements indicated good exciton mobilities in condensed phase. Fluorescence quenching by nitroaromatic aqueous solutions was fast, complete, selective and reversible pointing to a rapid diffusion of analytes into the films. The quenching response to nitrophenols was superior to that against nitrotoluenes. The increase of the electron-donating capabilities by diethoxy-substitution was detrimental to the amorphous morphology and it did not increase sensitivity to NACs. Quenching efficiencies of polymers were not modified when MeOH was used instead of water. The solubility parameter distances, Ra. indicate that the sensing materials show higher responses when their affinity with the analytes is lower. This observation could help in the designing of fluorescent sensors.
- Almassio, Marcela F.,Romagnoli, Maria J.,Del Rosso, Pablo G.,Schvval, Ana Belén,Garay, Raúl O.
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p. 167 - 179
(2017/03/02)
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- Asymmetric Pentafulvene Carbometalation - Access to Enantiopure Titanocene Dichlorides of Biological Relevance
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Unprecedented asymmetric copper-catalyzed addition of ZnEt2 (ZnBu2) to the exocyclic C=C bond of pentafulvenes C5H4(=CHAr) (Ar=2-MeOPh and related species) results in enantiomerically enriched (up to 93:7 e.r.)
- Cini, Melchior,Bradshaw, Tracey D.,Woodward, Simon,Lewis, William
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supporting information
p. 14179 - 14182
(2016/01/25)
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- Unsymmetric salen ligands bearing a Lewis base: Intramolecularly cooperative catalysis for cyanosilylation of aldehydes
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A series of unsymmetric salen ligands derived from 1,2-diaminocyclohexane bearing an appended Lewis base on the three-position of one aromatic ring were synthesized by the reaction of various functional salicyaldehydes with the condensation product of 1,2-diaminocyclohexane mono(hydrogen chloride) and 3,5-di-tert-butylsalicylaldehyde. These ligands in conjunction with Ti(O iPr)4 exhibited excellent activity in catalyzing the cyanosilylation of aldehydes with trimethylsilyl cyanide (TMSCN) at mild conditions. The highest activity was observed in the catalyst system with regard to the salen ligand bearing a diethylamino group, which proved to be active even at a high [aldehyde]/[catalyst] ratio up to 50000. In a low catalyst loading of 0.05 mol%, the quantitative conversion of benzaldehyde to the corresponding cyanosilylation product was found within 10 min. at ambient temperature. An intramolecularly cooperative catalysis was proposed wherein the central metal Ti(iv) is suggested to play a role of Lewis acid to activate aldehydes while the appended Lewis base to activate TMSCN.
- Wen, Ye-Qian,Ren, Wei-Min,Lu, Xiao-Bing
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scheme or table
p. 6323 - 6330
(2011/10/09)
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- Mechanistic aspects of the copolymerization of CO2 with epoxides using a thermally stable single-site cobalt(III) catalyst
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The mechanism of the copolymerization of CO2 and epoxides to afford the corresponding polycarbonates catalyzed by a highly active and thermally stable cobalt(III) complex with 1,5,7-triabicyclo[4,4,0] dec-5-ene (designated as TBD, a sterically
- Ren, Wei-Min,Liu, Zhong-Wen,Wen, Ye-Qian,Zhang, Rong,Lu, Xiao-Bing
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supporting information; experimental part
p. 11509 - 11518
(2011/03/21)
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- NMR investigation of hydrogen bonding and 1,3-tautomerism in 2-(2-hydroxy-5-substituted-aryl) benzimidazoles
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The 1,3-tautomerism associated with 2-(2-hydroxy-5-substituted-aryl) benzimidazoles was studied in different solvents. The effect of hydrogen bonding involving the hydroxyl group of the 2-aryl ring on the tautomerism was investigated using NMR spectroscopy. The influence of the solvent concentration on 2-(2-hydroxy-5-chloroaryl)benzimidazole was studied in acetone-d6 and DMSO-d6. Copyright
- Sridharan,Saravanan,Muthusubramanian,Sivasubramanian
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p. 551 - 556
(2007/10/03)
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- Microwave assisted synthesis of α -(5-substituted-2-hydroxyaryl)-N-aryl nitrones and their NMR and mass spectral studies
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This article describes the microwave assisted synthesis of several new α-(5-substituted-2-hydroxyaryl)-N-aryl nitrones. The synthesized compounds are fully characterized by their one dimensional and two dimensional NMR spectra. The interesting features of their mass spectra are discussed.
- Sridharan,Muthusubramanian,Sivasubramanian
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p. 857 - 863
(2007/10/03)
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- Mono- and diformylation of 4-substituted phenols: A new application of the duff reaction
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Careful control of the reaction conditions in a modified Duff reaction using anhydrous trifluoroacetic acid as the solvent enables the selective synthesis of either 4-substituted 2-formylphenols (5-substituted salicylaldehydes) or 4-substituted 2,6-diformylphenols in one step starting from commercially available 4-substituted phenols in moderate to good yield.
- Lindoy, Leonard F.,Meehan, George V.,Svenstrup, Niels
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p. 1029 - 1032
(2007/10/03)
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- Artificial transaminases linking pyridoxamine to binding cavities: Controlling the geometry
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A transaminase mimic joining a pyridoxamine unit to a cyclodextrin by a single linkage is quite selective for the conversion of phenylpyruvic acid to phenylalanine, compared with its reactivity toward nonbinding ketoacids. The selectivity is even greater
- Breslow, Ronald,Canary, James W.,Varney, Michael,Waddell, Sherman T.,Yang, Dan
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p. 5212 - 5219
(2007/10/02)
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