An improved procedure for the synthesis of fluoromethylketones: Flash vacuum pyrolytic elimination
Fluoromethylketones 3 are synthesized in good yields by a flash vacuum pyrolytic elimination of 2. Studies on the improved synthesis of 2 leads to the evidence on the existence of α,α-dilithio fluoromethyl phenyl sulfoxide.
FLUOROMETHYL PHENYL SULFOXIDE: HIGHLY CONVENIENT SYNTHESES OF VINYL FLUORIDES AND FLUOROMETHYLKETONES
Alkylation of lithio fluoromethyl phenyl sulfoxide 2 gave the alkylated products in high yields.Pyrolysis of the products led to vinyl fluorides in excellent yields.The reaction of 2 with carbonyl compounds led to the corresponding β-hydroxy-α-fluoromethyl phenyl sulfoxides.Pyrolysis of some of the sulfoxides gave fluoromethylketones in moderate yields.
Reutrakul, Vichai,Rukachaisirikul, Vatcharin
p. 725 - 728
(2007/10/02)
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