861206-26-0

Basic information

• Product Name: 3-IMIDAZO[2,1-B][1,3]THIAZOL-6-YLANILINE
• Synonyms: 3-IMIDAZO[2,1-B][1,3]THIAZOL-6-YLANILINE;3-IMIDAZO[2,1-B][1,3]THIAZOL-6-YLPHENYLAMINE;IFLAB-BB F1959-0001;TIMTEC-BB SBB011320;3-Imidazo[2,1-b]thiazol-6-yl-phenylamine;3-(Imidazo[2,1-b]thiazol-6-yl)aniline
• CAS NO: 861206-26-0
• Molecular Formula: C₁₁H₉N₃S
• Molecular Weight: 215.27
• Mol File: 861206-26-0.mol

Chemical Properties

• Appearance: /
• Density: 1.42±0.1 g/cm3(Predicted)
• PKA: 6.08±0.40(Predicted)
• CAS DataBase Reference: 3-IMIDAZO[2,1-B][1,3]THIAZOL-6-YLANILINE(CAS DataBase Reference)
• NIST Chemistry Reference: 3-IMIDAZO[2,1-B][1,3]THIAZOL-6-YLANILINE(861206-26-0)
• EPA Substance Registry System: 3-IMIDAZO[2,1-B][1,3]THIAZOL-6-YLANILINE(861206-26-0)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 861206-26-0(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
3-Imidazo[2,1-b][1,3]thiazol-6-ylaniline is used as a key intermediate in the synthesis of various pharmaceutical compounds for its antitumor, antimicrobial, and anti-inflammatory properties. Its imidazothiazole ring system serves as a valuable scaffold for the development of bioactive molecules, contributing to the creation of new drugs with potential therapeutic applications.
Used in Agrochemical Industry:
In the agrochemical sector, 3-Imidazo[2,1-b][1,3]thiazol-6-ylaniline is utilized as a building block for the development of novel agrochemicals. Its biological activities, such as antimicrobial properties, make it a promising candidate for the synthesis of compounds that can be used in crop protection and other agricultural applications to improve yield and control pests.

Downstream Products

• 670248-07-4 C₁₈H₁₃N₃OS 
• 1263131-96-9 N-(N-(3-(imidazo[2,1-b]thiazol-6-yl)phenyl)carbamimidoyl)-3,4,5-trimethoxybenzamide 
• 1192928-32-7 N-(3-(imidazo[2,1-b]thiazol-6-yl)phenylcarbamothioyl)-3,4,5-trimethoxybenzamide 

Relevant articles and documents

Acylthiourea, acylurea, and acylguanidine derivatives with potent Hedgehog inhibiting activity

The Smoothened (Smo) receptor is the major transducer of the Hedgehog (Hh) signaling pathway. On the basis of the structure of the acylthiourea Smo antagonist (MRT-10), a number of different series of analogous compounds were prepared by ligand-based structural optimization. The acylthioureas, originally identified as actives, were converted into the corresponding acylureas or acylguanidines. In each series, similar structural trends delivered potent compounds with IC50 values in the nanomolar range with respect to the inhibition of the Hh signaling pathway in various cell-based assays and of BODIPY-cyclopamine binding to human Smo. The similarity of their biological activities, in spite of discrete structural differences, may reveal the existence of hydrogen-bonding interactions between the ligands and the receptor pocket. Biological potency of compounds 61, 72, and 86 (MRT-83) were comparable to those of the clinical candidate GDC-0449. These findings suggest that these original molecules will help delineate Smo and Hh functions and can be developed as potential anticancer agents.

IMIDAZO-THIAZOLE DERIVATIVES AS PROTEIN KINASE INHIBITORS

Compounds of formula I that inhibit protein kinases, compositions containing the compounds and methods of treating diseases using the compounds are disclosed. Formula I and therapeutically acceptable salts, prodrugs and salts of prodrugs thereof, wherein X is CH or N; A1 is R1, OR1. NHR1, N(R1)2, NHC(O)R1, NHC(O)NHR1, NHC(O)N(R1)2, NHC(O)OR1, C(O)NHR1, C(O)N(R1)2, C=NOR1, or C(NH2)NOC(O)R1;