861453-11-4 Usage
Uses
Used in Pharmaceutical Industry:
4-Methoxy-3-[3-(4-morpholinyl)propoxy]benzaldehyde is used as a building block for the synthesis of various pharmaceuticals. Its unique structure allows it to be a key component in the development of new drugs with potential therapeutic effects.
Used in Agrochemical Industry:
In the agrochemical sector, 4-Methoxy-3-[3-(4-morpholinyl)propoxy]benzaldehyde serves as a crucial intermediate in the production of agrochemicals. Its incorporation into these products can lead to enhanced pest control and crop protection.
Used in Organic Compounds Production:
4-Methoxy-3-[3-(4-morpholinyl)propoxy]benzaldehyde is utilized as an intermediate in the production of organic compounds with biological activity. Its presence in these compounds can contribute to their effectiveness in various applications, such as medicinal or industrial uses.
Used in Material Science:
4-Methoxy-3-[3-(4-morpholinyl)propoxy]benzaldehyde has been studied for its potential uses in the development of novel materials. Its unique properties may allow it to be integrated into new materials with specific characteristics, such as improved strength or chemical resistance.
Used as a Tool in Chemical Research:
4-Methoxy-3-[3-(4-morpholinyl)propoxy]benzaldehyde also serves as a valuable tool in chemical research. Its reactivity and structural features make it an interesting subject for studies aimed at understanding chemical reactions and developing new synthetic methods.
Check Digit Verification of cas no
The CAS Registry Mumber 861453-11-4 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 8,6,1,4,5 and 3 respectively; the second part has 2 digits, 1 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 861453-11:
(8*8)+(7*6)+(6*1)+(5*4)+(4*5)+(3*3)+(2*1)+(1*1)=164
164 % 10 = 4
So 861453-11-4 is a valid CAS Registry Number.
861453-11-4Relevant articles and documents
One-pot conversion of 2-nitrobenzonitriles to quinazolin-4(3H)-ones and synthesis of gefitinib and erlotinib hydrochloride
Chandregowda, Venkateshappa,Venkateswara Rao, Gudapati,Chandrasekara Reddy, Goukanapalli
, p. 39 - 48 (2008/02/02)
A simple and efficient one-pot conversion of 2-nitrobenzonitriles to quinazolin-4(3H)-ones involving reduction, formylation, hydrolysis and cyclization is reported. These quinazolinones have been used for making in economical way the anticancer drug molecules gefitinib (Iressa) and erlotinib HCl (Tarceva).
AN IMPROVED PROCESS FOR THE PREPARATION OF GEFITINIB
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Page/Page column 23, (2010/02/13)
Present invention discloses an improved process for the preparation of gefitinib (4-(3'-chloro-4'-fluorophenylamino)-7-methoxy-6-[3-(4-morpholinyl)propoxy]quinazoline), of formula-I, which comprises: (i) etherification of iso-vanillin with 3-morpholinopropyl halide, (ii) nitration using nitric acid, (iii) oximation, (iv) dehydration, (v) reduction-cum-hydrolysis, (vi) quinazolinone formation, (vii) introduction of a leaving group at C-4 position in quinozolinone, and (viii) condensation with 3-chloro4-fluoroaniline to get the crude gefitinib. Purification of crude gefitinib is achieved via acid/base treatment or by crystallization from solvents such as ethyl acetate, isopropanol, acetonitrile, and methyl ethyl ketone. Formula I, IX, XI, XIII, XV and XVI.
