Synthesis, in vitro and in vivo evaluation of 3-arylisoquinolinamines as potent antitumor agents
In the search for potent water-soluble 3-arylisoquinolines, several 3-arylisoquinolinamines were designed and synthesized. Various substituted 3-arylisoquinolinamines exhibited strong cytotoxic activity against eight different human cancer cell lines. In
Yang, Su Hui,Van, Hue Thi My,Le, Thanh Nguyen,Khadka, Daulat Bikram,Cho, Suk Hee,Lee, Kyung-Tae,Chung, Hwa-Jin,Lee, Sang Kook,Ahn, Chang-Ho,Lee, Young Bok,Cho, Won-Jea
scheme or table
p. 5277 - 5281
(2010/10/21)
5, 6, or 7-Substituted - 3-(hetero) arylisoquinolinamine derivatives and therapeutic use thereof
The present invention relates to 5, 6, or 7-substituted-3-(hetero)arylisoquinolinamine derivatives represented by general formula D, their pharmacologically acceptable salts thereof, and compositions containing such compounds. Methods for treating hyperproliferative disorders by administering the compounds are also included.
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Page/Page column 7-8
(2008/12/07)
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