Side-chain length is important for shogaols in protecting neuronal cells from β-amyloid insult
Ten shogaols were synthesized to evaluate the importance of the side-chain length in protecting cells from βA(1-42) insult using PC12 rat pheochromocytoma and IMR-32 human neuroblastoma cells. The compounds cell protectivity against βA insult was demonstrated using 3-[4,5- dimethylthiazol-2-yl]-2,5-diphenyltetrazolium bromide (MTT) reduction assay. The efficacy of cell protection from βA insult by these shogaols was shown to improve as the length of the side chain increase.
Kim, Darrick S. H. L.,Kim, Jin Yung
p. 1287 - 1289
(2007/10/03)
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