863870-82-0

Basic information

• Product Name: 2,3-DIIODOPHENYL N,N-DIETHYLCARBAMATE
• Synonyms: 2,3-DIIODOPHENYL N,N-DIETHYLCARBAMATE
• CAS NO: 863870-82-0
• Molecular Formula: C₁₁H₁₃I₂NO₂
• Molecular Weight: 445.04
• Mol File: 863870-82-0.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2,3-DIIODOPHENYL N,N-DIETHYLCARBAMATE(CAS DataBase Reference)
• NIST Chemistry Reference: 2,3-DIIODOPHENYL N,N-DIETHYLCARBAMATE(863870-82-0)
• EPA Substance Registry System: 2,3-DIIODOPHENYL N,N-DIETHYLCARBAMATE(863870-82-0)

Safety Data

• Hazardous Substances Data: 863870-82-0(Hazardous Substances Data)

Usage

Structure

Two iodine atoms attached to a phenyl ring, bonded to a diethylcarbamate functional group

Usage

Often used as a reagent in organic synthesis

Reactivity

Known for its ability to react with various nucleophiles

Manufacturing process

Multi-step process involving the reaction of phenyl magnesium bromide with carbon dioxide, followed by the addition of iodine

Toxicity

Toxic and can be harmful if ingested or inhaled

Storage

Should be stored in a cool, dry place away from direct sunlight and sources of ignition.

Upstream product

• 626-02-8 3-Iodophenol 
• 88-10-8 N,N-diethylcarbamyl chloride 
• 863870-73-9 O-3-iodophenyl N,N-diethylcarbamate 

Downstream Products

• 1380450-00-9 ((3-(2-bromoethoxy)-1,2-phenylene)bis(ethyne-2,1-diyl))dibenzene 
• 1380450-01-0 4,4'-((3-(2-bromoethoxy)-1,2-phenylene)bis(ethyne-2,1-diyl))bis(methylbenzene) 
• 1380450-02-1 4,4'-((3-(2-bromoethoxy)-1,2-phenylene)bis(ethyne-2,1-diyl))bis(fluorobenzene) 
• 1380450-03-2 4,4'-((3-(2-bromoethoxy)-1,2-phenylene)bis(ethyne-2,1-diyl))bis(methoxybenzene) 
• 1380450-04-3 ((3-(2-bromoethoxy)-1,2-phenylene)bis(ethyne-2,1-diyl))bis(trimethylsilane) 
• 1380450-05-4 1-(2-bromoethoxy)-2,3-diethynylbenzene 
• 1380450-10-1 (E)-5-benzylidene-4-phenyl-3,5-dihydro-2H-cyclopenta[de]chromene 
• 1380450-11-2 (E)-5-(4-methylbenzylidene)-4-(p-tolyl)-3,5-dihydro-2H-cyclopenta[de]chromene 
• 1380450-12-3 (E)-5-(4-fluorobenzylidene)-4-(4-fluorophenyl)-3,5-dihydro-2H-cyclopenta[de]chromene 
• 1380450-07-6 4,4'-((3-(2-iodoethoxy)-1,2-phenylene)bis(ethyne-2,1-diyl))bis(fluorobenzene) 
• 1380450-08-7 2-(4-fluorophenyl)-4-((4-fluorophenyl)ethynyl)benzofuran 
• 1380450-09-8 2,3-bis((4-fluorophenyl)ethynyl)phenol 
• 1380450-16-7 2,2'-((3-(2-bromoethoxy)-1,2-phenylene)bis(ethyne-2,1-diyl))bis((p-tolylethynyl)benzene) 
• 1380450-17-8 2,2'-((3-(2-bromoethoxy)-1,2-phenylene)bis(ethyne-2,1-diyl))bis((phenylethynyl)benzene) 

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Synthesis of 4-functionalized-1H-indoles from 2,3-dihalophenols

A new synthesis of 4-halo-1H-indoles has been developed from easily available 2,3-dihalophenol derivatives. The key steps are Smiles rearrangement and a one-pot or stepwise Sonogashira coupling/NaOH-mediated cyclization. Subsequent functionalization allows access to a wide variety of 2,4- or 2,3,4-regioselectively functionalized indoles.

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