86427-02-3 Usage
Uses
Used in Pharmaceutical Industry:
3-Chlorothiophene-2-carbonyl chloride is used as a key reactant in the synthesis of 5-(3-chlorothiophen-2-yl)-3-(4-trifluoromethylphenyl)-1,2,4-oxadiazole, a novel apoptosis inducer. 3-Chlorothiophene-2-carbonyl chloride has potential applications in the development of new therapeutic agents targeting cancer cells and promoting apoptosis, a process of programmed cell death.
Check Digit Verification of cas no
The CAS Registry Mumber 86427-02-3 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 8,6,4,2 and 7 respectively; the second part has 2 digits, 0 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 86427-02:
(7*8)+(6*6)+(5*4)+(4*2)+(3*7)+(2*0)+(1*2)=143
143 % 10 = 3
So 86427-02-3 is a valid CAS Registry Number.
InChI:InChI=1/C5H2Cl2OS/c6-3-1-2-9-4(3)5(7)8/h1-2H
86427-02-3Relevant articles and documents
Substituted 3-aryl-5-aryl-[1,2,4]-oxadiazoles and analogs as activators of caspases and inducers of apoptosis and the use thereof
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, (2008/06/13)
The present invention is directed to substituted 3-aryl-5-aryl-[1,2,4]-oxadiazoles and analogs thereof, represented by the Formula I: wherein Ar1, Ar3, A, B and D are defined herein. The present invention also relates to the discovery that compounds having Formula I are activators of caspases and inducers of apoptosis. Therefore, the activators of caspases and inducers of apoptosis of this invention may be used to induce cell death in a variety of clinical conditions in which uncontrolled growth and spread of abnormal cells occurs.
