- Iron-catalyzed Minisci acylation of N-heteroarenes with α-keto acids
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An efficient and mild protocol has been developed for the Minisci acylation reactions of nitrogen-containing heteroarenes with α-keto acids. Distinct from the conventional Minisci acylation conditions, the chemistry was performed using non-noble metal Fe(II), instead of expensive Ag(I) salt, as catalyst. A wide range of substrates, including aliphatic or aromatic α-keto acids, as well as various N-heteroarenes, proved to be compatible with the protocol. Scale-up experiment also demonstrates the practicality of the approach.
- Wang, Xiu-Zhi,Zeng, Cheng-Chu
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p. 1425 - 1430
(2019/02/01)
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- A New, Convenient Synthesis of Monoaroylpyrazines via Homolytic Substitution
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Reactions of 2-pyrazinecarboxylic acid (1) with aroyl radicals to give 5-aroyl-2-pyrazinecarboxylic acids 3 followed by decarboxylation provide convenient access to aryl 2-pyrazinyl ketones (2-aroylpyrazines) 4.
- Heinisch, G.,Loetsch, G.
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p. 119 - 121
(2007/10/02)
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- Preparation of Monoacylpyrazines
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Homolytic acylation of pyrazine and alkylpyrazines by aldehydes, as a source of an acyl radical, gives mainly monoacylation products.The reactions proceed in reasonable yields and provide a new route to pyrazine ketones.
- Houminer, Y.,Southwick, E. W.,Williams, D. L.
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p. 497 - 500
(2007/10/02)
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